α-Aethyl-cyclohexanaethanol

Base Information

• Chemical Name: α-Aethyl-cyclohexanaethanol
• CAS No.: 33204-52-3
• Molecular Formula: C₁₀H₂₀O
• Molecular Weight: 156.268
• Mol file: 33204-52-3.mol

Synonyms:α-Aethyl-cyclohexanaethanol

Chemical Property of α-Aethyl-cyclohexanaethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-Aethyl-cyclohexanaethanol

There total 9 articles about α-Aethyl-cyclohexanaethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-Cyclohexyl-butyric acid methyl ester (36613-93-1) → α-Aethyl-cyclohexanaethanol (33204-52-3)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; toluene; at 0 - 20 ℃;

DOI:10.1021/jo0347011

Reference yield: 77.0%

C16H31O5P (1375390-01-4) → α-Aethyl-cyclohexanaethanol (33204-52-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 12h; Cooling with ice; Inert atmosphere;

DOI:10.1055/s-0031-1290485

Reference yield:

vinylcyclohexane (695-12-5,25498-06-0) + triethylaluminum (97-93-8) → (2R)-2-cyclohexyl-1,4-butanediol (139592-41-9) + α-Aethyl-cyclohexanaethanol (33204-52-3) + (2S)-2-cyclohexylbutane-1,4-diol (139592-42-0)

Guidance literature:

vinylcyclohexane; triethylaluminum; With (p-S)(p-S)-bis[η⁵-[1-[(1S,2S,5R)-2-isopropyl-5-methylcyclohexyl]indenyl]]zirconium dichloride; In benzene; at 22 ℃; for 24h; Inert atmosphere; Schlenk technique;

With oxygen; In benzene; at 0 ℃; for 26h;

With hydrogenchloride; water; In benzene; at 0 ℃; enantioselective reaction;

DOI:10.1016/j.jorganchem.2012.10.021

upstream raw materials:

2-cyclohexyl-butyric acid

2-Cyclohexyl-butyric acid methyl ester

methyl cyclohexylacetate

Cyclohexylacetic acid

Downstream raw materials:

2-Cyclohexyl-butanal

4-Cyclohexyl-hexanol

4-Cyclohexyl-1-hexylbromid

sec-butylcyclohexane

Refernces

• 1、 Parfenova, Lyudmila V.,Kovyazin, Pavel V.,Tyumkina, Tatyana V.,Makrushina, Alyona V.,Khalilov, Leonard M.,Dzhemilev, Usein M.. "Catalytic enantioselective ethylalumination of terminal alkenes: Substrate effects and absolute configuration assignment". . p. 124 - 135. Retrieved 2015/02/19.
• 2、 Wong, Man-Kin,Chung, Nga-Wai,He, Lan,Wang, Xue-Chao,Yan, Zheng,Tang, Yeung-Chiu,Yang, Dan. "Investigation on the regioselectivities of intramolecular oxidation of unactivated C-H bonds by dioxiranes generated in Situ". . p. 6321 - 6328. Retrieved 2007/10/03.