Benzofuran, 7-nitro-

Base Information

• Chemical Name: Benzofuran, 7-nitro-
• CAS No.: 18761-32-5
• Molecular Formula: C8H5 N O3
• Molecular Weight: 163.13
• Mol file: 18761-32-5.mol

Synonyms:7-Nitrobenzofuran

Chemical Property of Benzofuran, 7-nitro-

Chemical Property:

• PSA: 58.96000
• LogP: 2.86420

Purity/Quality:

98% ^*data from raw suppliers

7-NITRO-BENZOFURAN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzofuran, 7-nitro-

There total 13 articles about Benzofuran, 7-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

7-nitrobenzofuran-2-carboxylic acid (90483-98-0) → nitro-7 benzofuranne (18761-32-5)

Guidance literature:

copper(II) oxide; In quinoline; at 170 ℃; for 1h;

Reference yield: 82.0%

1-nitro-3-(prop-1-enyl)-2-(prop-1-enyloxy)benzene (863659-51-2) → nitro-7 benzofuranne (18761-32-5)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In toluene; at 90 ℃; for 3h;

DOI:10.1016/j.tet.2005.05.090

Reference yield: 46.0%

2-nitro-6-(2-nitro-ethyl)-phenol → nitro-7 benzofuranne (18761-32-5)

Guidance literature:

2-nitro-6-(2-nitro-ethyl)-phenol; With sodium hydroxide; at 20 ℃; for 0.5h;

With sulfuric acid; at 0 - 20 ℃;

DOI:10.1055/s-2006-926250

upstream raw materials:

7-nitrobenzofuran-2-carboxylic acid

1-nitro-3-(prop-1-enyl)-2-(prop-1-enyloxy)benzene

3-nitrosalicylic aldehyde

3.1²-Dinitro-2-oxy-1-vinyl-benzol

Downstream raw materials:

3-chloro-1-benzofuran-7-amine

1-(7-benzofuranyl)-4-<3-(4-fluorobenzoyl)propyl>piperazine hydrochloride

2-<<4-(7-benzofuranyl)-1-piperazinyl>methyl>-5-(4-fluorophenyl)pyrrole

3-chloro-7-nitrobenzofuran

Refernces

• 1、 Zhang, Bang-Le,Wang, Fang-Dao,Yue, Jian-Min. "A new efficient method for the total synthesis of linear furocoumarins". . p. 567 - 570. Retrieved 2007/10/03.
• 2、 -. "ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION". Page 36-37. . Retrieved 2010/02/07.