2,4-Dimethoxypyridine

Base Information

• Chemical Name: 2,4-Dimethoxypyridine
• CAS No.: 18677-43-5
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40355849
• Wikidata: Q72468484
• Mol file: 18677-43-5.mol

Synonyms:2,4-dimethoxypyridine;18677-43-5;Pyridine, 2,4-dimethoxy-;MFCD01646187;SCHEMBL1206676;DTXSID40355849;AMY39293;BCP10991;AKOS002665932;AC-6268;CS-W018921;SB52696;AS-20048;SY031859;FT-0637736;EN300-93351;O10601;A813083;J-507237

Chemical Property of 2,4-Dimethoxypyridine

Chemical Property:

• Vapor Pressure: 1.82mmHg at 25°C
• Refractive Index: 1.427
• Boiling Point: 201.4 °C at 760 mmHg
• Flash Point: 72.4 °C
• PSA: 31.35000
• Density: 1.064 g/cm³
• LogP: 1.09880
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

98% ^*data from raw suppliers

2,4-DimethoxypyridineI ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=NC=C1)OC

Technology Process of 2,4-Dimethoxypyridine

There total 12 articles about 2,4-Dimethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,4-dichloropyridine (26452-80-2) + sodium methylate (124-41-4) → 2,4-dimethoxypyridine (18677-43-5)

Guidance literature:

at 120 ℃; for 6h; Inert atmosphere;

DOI:10.3184/174751918X15166150010920

Reference yield: 58.0%

2-chloro-4-methoxy-pyridine (17228-69-2) + sodium methylate (124-41-4) → 2,4-dimethoxypyridine (18677-43-5)

Guidance literature:

With methanol; Heating / reflux;

Reference yield:

3-bromo-2,4-dimethoxypyridine (96246-00-3) → 2,4-dimethoxypyridine (18677-43-5)

Guidance literature:

With sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; at 23 ℃; for 2h; under 2052 Torr;

DOI:10.1021/jo00214a012

upstream raw materials:

2,4-dichloropyridine

sodium methylate

2-bromo-4,6-dimethoxypyridine

3-bromo-2,4-dimethoxypyridine

Downstream raw materials:

4-methoxy-1-methyl-2-pyridone

4-methoxypyridin-2-ol

3-deazauracil

5-bromo-2,4-dimethoxypyridine

Refernces

• 1、 -. "ANTI-FIBROTIC PYRIDINONES". Paragraph 0677. . Retrieved 2015/11/02.
• 2、 -. "CHEMICAL COMPOUNDS AND PROCESSES". Page/Page column 74. . Retrieved 2008/12/06.