Oxiranecarboxamide, 3-phenyl- (9CI)

Base Information

• Chemical Name: Oxiranecarboxamide, 3-phenyl- (9CI)
• CAS No.: 18538-53-9
• Molecular Formula: C9H9 N O2
• Molecular Weight: 163.176
• Mol file: 18538-53-9.mol

Synonyms:Glycidamide,3-phenyl- (7CI); Hydrocinnamamide, 2,3-epoxy- (8CI); Oxiranecarboxamide,3-phenyl- (9CI)

Chemical Property of Oxiranecarboxamide, 3-phenyl- (9CI)

Chemical Property:

• PSA: 55.62000
• LogP: 1.31210

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxiranecarboxamide, 3-phenyl- (9CI)

There total 10 articles about Oxiranecarboxamide, 3-phenyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

cinnamamide (621-79-4,22031-64-7) → 2,3-epoxy-3-phenylpropionamide (18538-53-9)

Guidance literature:

With 1,2-diphenyl-1,1,2,2-tetrahydroperoxyethane; potassium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 4h; Green chemistry;

DOI:10.1002/jccs.201700026

Reference yield: 76.0%

cinnamamide (621-79-4,22031-64-7) → 2,3-epoxy-3-phenylpropionamide (18538-53-9,19464-96-1,79836-11-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 50 ℃;

DOI:10.1016/j.tet.2009.02.013

Reference yield: 75.0%

cinnamamide (621-79-4) → 2,3-epoxy-3-phenylpropionamide (18538-53-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03029

upstream raw materials:

bromo-acetic acid amide

benzaldehyde

cinnamamide

Chloroacetamide

Downstream raw materials:

(2RS,3RS)-3-anilino-2-hydroxy-3-phenyl-propionic acid amide

(2R,3S)-3-phenyloxirane-2-carboxamide

cinnamamide

(Z)-2-hydroxy-3-phenyl-acrylic acid

Refernces

• 1、 Mamedov,Mamedova,Khikmatova,Korshin,Sinyashin. "5-(α-Halobenzyl)- and 5-Benzylidene-2,2-dimethyl-1,3-oxazolidin-4-ones in Synthesis of α-Hydroxy Acids". . p. 2801 - 2809. Retrieved 2018/02/21.
• 2、 Mamedov,Mamedova,Khikmatova,Krivolapov,Litvinov. "Synthesis of 5-[bromo(aryl)methyl]-2,2-dimethyl-1,3-oxazolidin-4-ones". . p. 1260 - 1267. Retrieved 2017/02/05.