1-(11-(2-hydroxyphenylthio)undec-5(Z)-enyl)-3-n-pentylurea

Base Information

• Chemical Name: 1-(11-(2-hydroxyphenylthio)undec-5(Z)-enyl)-3-n-pentylurea
• CAS No.: 1402547-53-8
• Molecular Formula: C₂₃H₃₈N₂O₂S
• Molecular Weight: 406.633
• Mol file: 1402547-53-8.mol

Synonyms:1-(11-(2-hydroxyphenylthio)undec-5(Z)-enyl)-3-n-pentylurea

Chemical Property of 1-(11-(2-hydroxyphenylthio)undec-5(Z)-enyl)-3-n-pentylurea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(11-(2-hydroxyphenylthio)undec-5(Z)-enyl)-3-n-pentylurea

There total 9 articles about 1-(11-(2-hydroxyphenylthio)undec-5(Z)-enyl)-3-n-pentylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

ortho-mercaptophenol (1121-24-0) + 1-(11-bromoundec-5(Z)-enyl)-3-n-pentylurea (1402548-16-6) → 1-(11-(2-hydroxyphenylthio)undec-5(Z)-enyl)-3-n-pentylurea (1402547-53-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield: 69.0%

ortho-mercaptophenol (1121-24-0) + 1-(12-bromododec-5(Z)-enyl)-3-n-pentylurea (1402547-89-0) → 1-(11-(2-hydroxyphenylthio)undec-5(Z)-enyl)-3-n-pentylurea (1402547-53-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1021/jm500262m

Reference yield:

tert-butyldiphenyl-[(12-(tetrahydro-2H-pyran-2-yloxy)dodec-7-ynyloxy)]silane (622842-63-1) → 1-(11-(2-hydroxyphenylthio)undec-5(Z)-enyl)-3-n-pentylurea (1402547-53-8)

Guidance literature:

Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / methanol / 10 h / 20 °C

2.1: nickel(II) acetate tetrahydrate; hydrogen / ethanol / 20 °C

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere

3.2: 4 h / 20 °C

4.1: triphenylphosphine / tetrahydrofuran; water / 12 h

5.1: tetrahydrofuran / 3 h / 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

7.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 2 h / 0 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With carbon tetrabromide; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; nickel(II) acetate tetrahydrate; potassium carbonate; toluene-4-sulfonic acid; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm500262m

upstream raw materials:

ortho-mercaptophenol

1-(11-bromoundec-5(Z)-enyl)-3-n-pentylurea

tert-butyldiphenyl-[(12-(tetrahydro-2H-pyran-2-yloxy)dodec-7-ynyloxy)]silane

1-(12-bromododec-5(Z)-enyl)-3-n-pentylurea

Downstream raw materials:

1-(11-(2-hydroxyphenylsulfonyl)undec-5(Z)-enyl)-3-n-pentylurea

Refernces

• 1、 -. "EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME". Page/Page column 53. . Retrieved 2012/10/18.