Ketone, 3aalpha,4,5,6,7,7a-hexahydro-7abeta-methyl-1beta-indanyl methy l

Base Information

• Chemical Name: Ketone, 3aalpha,4,5,6,7,7a-hexahydro-7abeta-methyl-1beta-indanyl methy l
• CAS No.: 16510-55-7
• Molecular Formula: C₁₂H₂₀O
• Molecular Weight: 180.29
• Mol file: 16510-55-7.mol

Synonyms:Ketone,3aa,4,5,6,7,7a-hexahydro-7ab-methyl-1b-indanyl methyl (8CI)

Chemical Property of Ketone, 3aalpha,4,5,6,7,7a-hexahydro-7abeta-methyl-1beta-indanyl methy l

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ketone, 3aalpha,4,5,6,7,7a-hexahydro-7abeta-methyl-1beta-indanyl methy l

There total 13 articles about Ketone, 3aalpha,4,5,6,7,7a-hexahydro-7abeta-methyl-1beta-indanyl methy l which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyllithium (917-54-4) + C11H18O2 → 1-trans-Acetyl-7a-cis-methyl-3arefH-hydrindan (16510-55-7,17986-87-7,17986-96-8,17986-97-9,31653-53-9,31653-54-0,31653-55-1,31653-56-2,54832-11-0) + all-cis-1-Acetyl-7a-methyl-hydrindan (16510-55-7,17986-87-7,17986-96-8,17986-97-9,31653-53-9,31653-54-0,31653-55-1,31653-56-2,54832-11-0)

Guidance literature:

methyllithium; C₁₁H₁₈O₂; In tetrahydrofuran; hexane; at 0 ℃; for 2h; Inert atmosphere;

With chloro-trimethyl-silane; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; hexane; water; at 20 ℃; for 4.5h; Overall yield = 42 percent; Overall yield = 62 mg;

DOI:10.1055/s-0039-1690727

Reference yield:

methyllithium (917-54-4) + C11H18O2 → 1-trans-Acetyl-7a-cis-methyl-3arefH-hydrindan (16510-55-7,17986-87-7,17986-96-8,17986-97-9,31653-53-9,31653-54-0,31653-55-1,31653-56-2,54832-11-0) + all-cis-1-Acetyl-7a-methyl-hydrindan (16510-55-7,17986-87-7,17986-96-8,17986-97-9,31653-53-9,31653-54-0,31653-55-1,31653-56-2,54832-11-0)

Guidance literature:

methyllithium; C₁₁H₁₈O₂; In tetrahydrofuran; hexane; at 0 ℃; for 2h; Inert atmosphere;

With chloro-trimethyl-silane; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; hexane; water; at 20 ℃; for 4.5h; Overall yield = 42 percent; Overall yield = 62 mg;

DOI:10.1055/s-0039-1690727

Reference yield:

1-[3-(2-methyl-[1,3]dioxolan-2-yl)-propyl]-2-oxo-cyclohexanecarboxylic acid ethyl ester (97834-67-8) → 1-trans-Acetyl-7a-cis-methyl-3arefH-hydrindan (16510-55-7,17986-87-7,17986-96-8,17986-97-9,31653-53-9,31653-54-0,31653-55-1,31653-56-2,54832-11-0)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. NaOH / Heating

3: H₂SO₄ / acetone

4: H₂O / 1.5 h / 355 °C

With sodium hydroxide; sulfuric acid; water; In acetone;

upstream raw materials:

1-<2-Methylen-cyclohexyl>-pentanon-(4)

(+-)-7a-methyl-cis-hexahydro-indan-1-one

ethyltriphenylphosphonium iodide

1-[3-(2-methyl-[1,3]dioxolan-2-yl)-propyl]-2-oxo-cyclohexanecarboxylic acid ethyl ester

Refernces

• 1、 Zeeh,Jones,Djerassi. "Fragmentation behavior and synthesis of bicyclic and monocyclic models of the 20-ketosteroids". . p. 1018 - 1034. Retrieved 2007/10/10.