C₂₄H₂₉N₃O₃S

Base Information

• Chemical Name: C₂₄H₂₉N₃O₃S
• CAS No.: 1453175-45-5
• Molecular Formula: C₂₄H₂₉N₃O₃S
• Molecular Weight: 439.579
• Mol file: 1453175-45-5.mol

Synonyms:C₂₄H₂₉N₃O₃S

Chemical Property of C₂₄H₂₉N₃O₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₉N₃O₃S

There total 7 articles about C₂₄H₂₉N₃O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

furo[2,3-c]pyridine-2-carboxylic acid 4-(1-isobutylpiperidine-4-sulfinyl)benzylamide (1453175-37-5) → C24H29N3O3S (1453175-46-6) + C24H29N3O3S (1453175-45-5)

Guidance literature:

With Column, Chiralpak IC2*25 cm, 5 μm Chiral164 P(IC)001 ICOOCJ-L0016; In ethanol; hexane; at 25 ℃; under 60006 - 67506.8 Torr; Resolution of racemate;

Reference yield:

3-hydroxyisonicotinic acid (10128-71-9) → C24H29N3O3S (1453175-46-6) + C24H29N3O3S (1453175-45-5)

Guidance literature:

Multi-step reaction with 8 steps

1: sulfuric acid / 72 h / Reflux

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / -10 - 20 °C

3: sodium hydride / tetrahydrofuran; mineral oil / 16 h / 0 - 20 °C / Inert atmosphere

4: pyridine / dichloromethane / 16 h / 0 - 20 °C

5: palladium 10% on activated carbon; triethylamine; hydrogen / ethanol / 16 h / 760.05 Torr

6: potassium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

8: Column, Chiralpak IC2*25 cm, 5 μm Chiral164 P(IC)001 ICOOCJ-L0016 / ethanol; hexane / 25 °C / 60006 - 67506.8 Torr / Resolution of racemate

With pyridine; di-isopropyl azodicarboxylate; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

ethyl 3-hydroxyisonicotinate (18342-97-7) → C24H29N3O3S (1453175-46-6) + C24H29N3O3S (1453175-45-5)

Guidance literature:

Multi-step reaction with 7 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / -10 - 20 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 16 h / 0 - 20 °C / Inert atmosphere

3: pyridine / dichloromethane / 16 h / 0 - 20 °C

4: palladium 10% on activated carbon; triethylamine; hydrogen / ethanol / 16 h / 760.05 Torr

5: potassium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

7: Column, Chiralpak IC2*25 cm, 5 μm Chiral164 P(IC)001 ICOOCJ-L0016 / ethanol; hexane / 25 °C / 60006 - 67506.8 Torr / Resolution of racemate

With pyridine; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; water; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

furo[2,3-c]pyridine-2-carboxylic acid 4-(1-isobutylpiperidine-4-sulfinyl)benzylamide

3-hydroxyisonicotinic acid

ethyl 3-hydroxyisonicotinate

Ethyl 2-(4-Ethoxycarbonyl-3-pyridyloxy) acetate

Refernces

• 1、 -. "AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES". Page/Page column 164; 166. . Retrieved 2013/09/12.