4-METHOXYPHENYL VINYLSULPHONE

Base Information

• Chemical Name: 4-METHOXYPHENYL VINYLSULPHONE
• CAS No.: 16191-87-0
• Molecular Formula: C9H10 O3 S
• Molecular Weight: 198.243
• Hs Code.: 2909309090
• Mol file: 16191-87-0.mol

Synonyms:Anisole,p-(vinylsulfonyl)- (7CI,8CI); 4-Methoxyphenyl vinyl sulfone;5-(Ethenesulfonyl)-2-methoxybenzene; p-Anisyl vinyl sulfone; p-Methoxyphenylvinyl sulfone

Chemical Property of 4-METHOXYPHENYL VINYLSULPHONE

Chemical Property:

• Boiling Point: 352.3±34.0 °C(Predicted)
• PSA: 51.75000
• Density: 1.188±0.06 g/cm3(Predicted)
• LogP: 3.30500

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXYPHENYL VINYLSULPHONE

There total 7 articles about 4-METHOXYPHENYL VINYLSULPHONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

PVS (5535-48-8) + 4-methoxy-N-morpholinobenzenesulfonamide (557780-43-5) + ethylene dibromide (106-93-4) → 1-(vinylsulfonyl)-4-methoxybenzene (16191-87-0) + (E)-N-(2-(phenylsulfonyl)ethylidene)morpholin-4-amine + (E)-N-(2-(4-methoxyphenylsulfonyl)ethylidene)morpholin-4-amine

Guidance literature:

With caesium carbonate; In acetonitrile; at 40 ℃;

DOI:10.1039/c5ob01765c

Reference yield:

1-[(4-methoxyphenyl)-sulfonyl]ethan-2-ol (35848-00-1) + methanesulfonyl chloride (124-63-0) → 1-(vinylsulfonyl)-4-methoxybenzene (16191-87-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield:

C9H11BrO3S → 1-(vinylsulfonyl)-4-methoxybenzene (16191-87-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b02867

upstream raw materials:

1-(2-chloroethylsulfonyl)-4-methoxybenzene

1-(2-chloro-ethylsulfanyl)-4-methoxy-benzene

1-[(4-methoxyphenyl)-sulfonyl]ethan-2-ol

methanesulfonyl chloride

Downstream raw materials:

4-[2-(4-methoxy-benzenesulfonyl)-ethyl]-morpholine

C₁₈H₂₀O₆S₂

1-(2-tert-Butylperoxy-ethanesulfonyl)-4-methoxy-benzene

1-Methoxy-4-[2-(1-methyl-1-phenyl-ethylperoxy)-ethanesulfonyl]-benzene

Refernces

• 1、 Blackburn, Bryan G.,Cooke, Maria Victoria,Laulhé, Sébastien,Niu, Ben,Sachidanandan, Krishnakumar. "Metal-free visible-light-promoted C(sp3)-H functionalization of aliphatic cyclic ethers using trace O2". supporting information. p. 9454 - 9459. Retrieved 2021/12/09.
• 2、 Hock, Katharina J.,Mertens, Lucas,Metze, Friederike K.,Schmittmann, Clemens,Koenigs, Rene M.. "Difluoro- and trifluoro diazoalkanes-complementary approaches in batch and flow and their application in cycloaddition reactions". supporting information. p. 905 - 909. Retrieved 2017/08/14.