Technology Process of (±)-O-benzylarmepavine
There total 9 articles about (±)-O-benzylarmepavine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium cyanoborohydride;
In
tetrahydrofuran; ethanol;
at 0 - 20 ℃;
for 13h;
Inert atmosphere;
DOI:10.1021/jo400659n
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 2 h / Cooling with ice; Reflux; Inert atmosphere
2: phosphorus pentachloride / dichloromethane / 1.5 h / 35 - 40 °C / Inert atmosphere
3: diethyl ether / 20 °C / Inert atmosphere
4: water / 20 °C
5: tetrahydrofuran / 72 h / 40 °C / Inert atmosphere
6: potassium hexamethylsilazane / tetrahydrofuran / 0 °C / Inert atmosphere
7: sodium cyanoborohydride / ethanol; tetrahydrofuran / 13 h / 0 - 20 °C / Inert atmosphere
With
phosphorus pentachloride; potassium hexamethylsilazane; sodium cyanoborohydride;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;
2: |Bischler-Napieralski Reaction / 6: |Stevens Rearrangement;
DOI:10.1021/jo400659n
- Guidance literature:
-
Multi-step reaction with 5 steps
1: diethyl ether / 20 °C / Inert atmosphere
2: water / 20 °C
3: tetrahydrofuran / 72 h / 40 °C / Inert atmosphere
4: potassium hexamethylsilazane / tetrahydrofuran / 0 °C / Inert atmosphere
5: sodium cyanoborohydride / ethanol; tetrahydrofuran / 13 h / 0 - 20 °C / Inert atmosphere
With
potassium hexamethylsilazane; sodium cyanoborohydride;
In
tetrahydrofuran; diethyl ether; ethanol; water;
4: |Stevens Rearrangement;
DOI:10.1021/jo400659n
