6-Chloro-2-methylimidazo[1,2-b]pyridazine

Base Information

• Chemical Name: 6-Chloro-2-methylimidazo[1,2-b]pyridazine
• CAS No.: 14793-00-1
• Molecular Formula: C7H6ClN3
• Molecular Weight: 167.598
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60439897
• Nikkaji Number: J151.387G
• Wikidata: Q72454092
• Mol file: 14793-00-1.mol

Synonyms:6-chloro-2-methylimidazo[1,2-b]pyridazine;14793-00-1;Imidazo[1,2-b]pyridazine, 6-chloro-2-methyl-;6-chloro-2-methyl-imidazo[1,2-b]pyridazine;MFCD07778346;IMIDAZO[1,2-B]PYRIDAZINE,6-CHLORO-2-METHYL-;SCHEMBL477109;DTXSID60439897;GWHLOBFYCUGPGE-UHFFFAOYSA-N;AMY14053;AKOS006285402;CS-W006591;FS-3729;SB15372;SY111606;6-Chloro-2-methylimidazo [1,2-b]pyridazine;FT-0694785;EN300-3477208;A808708;J-518531;Z1198174189

Chemical Property of 6-Chloro-2-methylimidazo[1,2-b]pyridazine

Chemical Property:

• Refractive Index: 1.681
• PKA: 4.70±0.30(Predicted)
• PSA: 30.19000
• Density: 1.436 g/cm³
• LogP: 1.69110
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 167.0250249
• Heavy Atom Count: 11
• Complexity: 153

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Chloro-2-methylimidazo[1,2-b]pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN2C(=N1)C=CC(=N2)Cl

Technology Process of 6-Chloro-2-methylimidazo[1,2-b]pyridazine

There total 3 articles about 6-Chloro-2-methylimidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

6-chloro-pyridazin-3-ylamine (5469-69-2) + chloroacetone (78-95-5) → 6-chloro-2-methylimidazo-<1,2-b>pyridazine (14793-00-1)

Guidance literature:

With triethylamine; In ethanol; at 150 ℃; for 0.5h;

Reference yield: 16.0%

6-chloro-pyridazin-3-ylamine (5469-69-2) + 1-bromo-2,2-dimethoxypropane (126-38-5) → 6-chloro-2-methylimidazo-<1,2-b>pyridazine (14793-00-1)

Guidance literature:

In acetonitrile; at 100 ℃; for 16h;

Reference yield:

→ 6-chloro-2-methylimidazo-<1,2-b>pyridazine (14793-00-1)

Guidance literature:

6-Chlor-2-methyl-imidazo<1,2-b>pyridazin-carbonsaeure, Decarboxylierung (230-240grad, Cu-Bronze);

DOI:10.1016/0040-4020(67)85139-1

upstream raw materials:

6-chloro-pyridazin-3-ylamine

chloroacetone

1-bromo-2,2-dimethoxypropane

Downstream raw materials:

6-(4'-methoxy-biphenyl-4-yl)-2-methyl-imidazo[1,2-b]pyridazine

3-bromo-6-chloro-2-methylimidazo/1,2-b/pyridazine

6-(4-methanesulfonyl-phenyl)-2-methyl-imidazo[1,2-b]pyridazine

C₁₄H₁₃N₃O₂

Refernces

• 1、 -. "Compounds for treating spinal muscular atrophy". Page/Page column 409; 410. . Retrieved 2017/05/02.
• 2、 -. "Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof". Page/Page column 348. . Retrieved 2016/04/26.