2-(4-ethylphenyl)-2-oxoacetaldehyde hydrate

Base Information

• Chemical Name: 2-(4-ethylphenyl)-2-oxoacetaldehyde hydrate
• CAS No.: 14333-92-7
• Molecular Formula: C10H10 O2
• Molecular Weight: 162.188
• Mol file: 14333-92-7.mol

Synonyms:Glyoxal,(p-ethylphenyl)- (8CI); 4-Ethylphenylglyoxal; p-Ethylphenylglyoxal

Chemical Property of 2-(4-ethylphenyl)-2-oxoacetaldehyde hydrate

Chemical Property:

• PSA: 34.14000
• LogP: 1.63060

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-ethylphenyl)-2-oxoacetaldehyde hydrate

There total 4 articles about 2-(4-ethylphenyl)-2-oxoacetaldehyde hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

4-ethylacetophenone (937-30-4) → 2-(4-ethylphenyl)-2-oxoacetaldehyde (14333-92-7)

Guidance literature:

With water; hydrogen bromide; dimethyl sulfoxide; at 20 - 70 ℃;

Reference yield:

1-ethenyl-4-ethyl-benzene (3454-07-7) → 2-(4-ethylphenyl)-2-oxoacetaldehyde (14333-92-7)

Guidance literature:

With iodine; dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; at 100 ℃;

DOI:10.1039/c4cc05844e

Reference yield:

1-ethyl-4-ethynylbenzene (40307-11-7) → 2-(4-ethylphenyl)-2-oxoacetaldehyde (14333-92-7)

Guidance literature:

With iodine; dimethyl sulfoxide; at 80 ℃; for 2h;

DOI:10.1021/acs.orglett.1c01243

upstream raw materials:

4-ethylacetophenone

1-ethenyl-4-ethyl-benzene

1-ethyl-4-ethynylbenzene

Downstream raw materials:

2-(4-ethylphenyl)quinoxaline

2-(4'-ethylphenyl)-3-methoxy-6-(2-methoxyphenoxy)imidazo<1,2-b>pyridazine

Refernces

• 1、 Viswanadham, K. K. Durga Rao,Prathap Reddy, Muktapuram,Sathyanarayana, Pochampalli,Ravi, Owk,Kant, Ruchir,Bathula, Surendar Reddy. "Iodine-mediated oxidative annulation for one-pot synthesis of pyrazines and quinoxalines using a multipathway coupled domino strategy". supporting information. p. 13517 - 13520. Retrieved 2015/01/09.