ethyl 3-(3,4,5,6-tetrahydro-2H-pyran-4-yl) propionate

Base Information

• Chemical Name: ethyl 3-(3,4,5,6-tetrahydro-2H-pyran-4-yl) propionate
• CAS No.: 99197-84-9
• Molecular Formula: C₁₀H₁₈O₃
• Molecular Weight: 186.251
• Mol file: 99197-84-9.mol

Synonyms:ethyl 3-(3,4,5,6-tetrahydro-2H-pyran-4-yl) propionate

Chemical Property of ethyl 3-(3,4,5,6-tetrahydro-2H-pyran-4-yl) propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(3,4,5,6-tetrahydro-2H-pyran-4-yl) propionate

There total 1 articles about ethyl 3-(3,4,5,6-tetrahydro-2H-pyran-4-yl) propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde (50675-18-8) → ethyl 3-(3,4,5,6-tetrahydro-2H-pyran-4-yl) propionate (99197-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 1 h / Heating

2: H₂ / 10 percent Pd-C / ethanol / Ambient temperature

With hydrogen; palladium on activated charcoal; In ethanol; benzene;

DOI:10.1248/cpb.34.1128

Reference yield:

ethyl 3-(3,4,5,6-tetrahydro-2H-pyran-4-yl) propionate (99197-84-9) → (S)-2-(4-(cyclopropylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl)-3-(tetrahydro-2H-pyran-4-yl)propanoate (R)-N-(4-(dimethylamino)benzyl)-1-phenylethanaminium salt (1373168-71-8)

Guidance literature:

Multi-step reaction with 8 steps

1.1: sodium hydroxide; water / ethanol / 16 h

1.2: 1 h / 0 - 5 °C / pH 1

2.1: thionyl chloride / N,N-dimethyl-formamide / chlorobenzene / 1.5 h / 21 °C

3.1: bromine / chlorobenzene / 20 h / 85 - 90 °C

4.1: water / chlorobenzene / 21 h / 0 - 5 °C

5.1: sulfurous dibromide / 16 h / 40 - 60 °C / Industry scale

6.1: caesium carbonate / butanone / 0.28 h / Industry scale

6.2: 13.8 h / 54 °C / Industry scale

7.1: sodium hydroxide; water / butanone / 1.72 h / 12 - 18 °C / Industry scale

7.2: 3 h / pH 3.2 / Industry scale

8.1: isopropyl alcohol; water / 20 - 70 °C / Industry scale

With sulfurous dibromide; thionyl chloride; water; bromine; caesium carbonate; sodium hydroxide; N,N-dimethyl-formamide; In ethanol; water; chlorobenzene; isopropyl alcohol; butanone;

Reference yield:

ethyl 3-(3,4,5,6-tetrahydro-2H-pyran-4-yl) propionate (99197-84-9) → (R)-2-((S)-9-Benzyloxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-(tetrahydro-pyran-4-yl)-butyric acid ethyl ester (99197-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaOEt; 2) H₂SO₄, LiCl / 1) EtOH, 70 deg C, 60 min; 2) DMSO, 140 deg C, 2.5 h

2: 26 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

With 4 A molecular sieve; sulfuric acid; sodium ethanolate; sodium cyanoborohydride; lithium chloride; In ethanol; acetic acid;

DOI:10.1248/cpb.34.1128

upstream raw materials:

3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

Downstream raw materials:

3-tetrahydropyran-4-yl-propan-1-ol

(R)-2-((S)-9-Benzyloxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-(tetrahydro-pyran-4-yl)-butyric acid ethyl ester

(S)-2-((S)-9-Benzyloxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-(tetrahydro-pyran-4-yl)-butyric acid ethyl ester

3-(tetrahydro-2H-pyran-4-yl)propanoic acid

Refernces