2-(3-AMINO-PHENYL)-BENZOOXAZOL-5-YLAMINE

Base Information

• Chemical Name: 2-(3-AMINO-PHENYL)-BENZOOXAZOL-5-YLAMINE
• CAS No.: 13676-47-6
• Molecular Formula: C13H11 N3 O
• Molecular Weight: 225.25
• Hs Code.: 2934999090
• Mol file: 13676-47-6.mol

Synonyms:Benzoxazole,5-amino-2-(p-aminophenyl)- (7CI,8CI); 2-(4-Aminophenyl)-5-aminobenzoxazole;5-Amino-2-(4-aminophenyl)benzoxazole; 5-Amino-2-(p-aminophenyl)benzoxazole

Chemical Property of 2-(3-AMINO-PHENYL)-BENZOOXAZOL-5-YLAMINE

Chemical Property:

• Vapor Pressure: 8.91E-08mmHg at 25°C
• Melting Point: 231-233°C
• Refractive Index: 1.729
• Boiling Point: 435.2°C at 760 mmHg
• PKA: 7.49±0.10(Predicted)
• Flash Point: 217°C
• PSA: 78.07000
• Density: 1.329
• LogP: 3.82160
• Storage Temp.: Refrigerator
• Solubility.: DMSO, Methanol

Purity/Quality:

98% ^*data from raw suppliers

5-Amino-2-(4-aminophenyl)benzoxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-AMINO-PHENYL)-BENZOOXAZOL-5-YLAMINE

There total 11 articles about 2-(3-AMINO-PHENYL)-BENZOOXAZOL-5-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

2-(4-nitrophenyl)-5-nitrobenzoxazole (1037-39-4) → 5-amino-2-(4'-aminophenyl)-benzoxazole (13676-47-6)

Guidance literature:

With phosphoric acid; sodium sulfite; In water; at 100 ℃; for 16h; pH=< 1;

Reference yield: 87.0%

1-ethoxyethanol (7518-70-9) + 2-(4-nitrophenyl)-5-nitrobenzoxazole (1037-39-4) → 5-amino-2-(4'-aminophenyl)-benzoxazole (13676-47-6)

Guidance literature:

With hydrogen; palladium-carbon; In water;

Reference yield:

4-nitrophenylchloroxime + 1-amino-4-nitrophenol + 4-nitrobenzaldoxime (1129-37-9,3717-19-9,3717-20-2,140461-32-1,174848-02-3,20707-69-1) + 2-hydroxy-5-nitroaniline (99-57-0) → 5-amino-2-(4'-aminophenyl)-benzoxazole (13676-47-6) + 2-(4-nitrophenyl)-5-nitrobenzoxazole (1037-39-4)

Guidance literature:

With hydrogenchloride; sodium hypochlorite; dmap; palladium; In 1,4-dioxane; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; water;

upstream raw materials:

2,4-diaminophenol dihydrochloride

4-amino-benzoic acid

4-nitrobenzaldoxime

2-hydroxy-5-nitroaniline

Downstream raw materials:

C₃₃H₄₁N₅O₇

2-chloro-N-(4-(5-(2-chloropropanamido)benzo[d]oxazol-2-yl)phenyl)propanamide

4-propyl-N-(4-(5-(4-propylbenzamido)benzo[d]oxazol-2-yl)phenyl)benzamide

4-chloro-2-nitro-N-(4-(5-(4-chloro-2-nitrobenzamido)benzo[d]oxazol-2-yl)phenyl)benzamide

Refernces

• 1、 -. "Benzoxazole ionic compound, PBO fiber emulsion sizing agent containing benzoxazole ionic compound and preparation method of PBO fiber emulsion sizing agent". Paragraph 0118-0119. . Retrieved 2020/11/05.
• 2、 -. "Preparation method of 2-(aminophenyl)-5-aminobenzoxazole". Paragraph 0030; 0034; 0035; 0038; 0042-0043. . Retrieved 2019/12/29.