3-Bromo-2,6-dimethoxypyridine

Base Information

• Chemical Name: 3-Bromo-2,6-dimethoxypyridine
• CAS No.: 13445-16-4
• Molecular Formula: C7H8BrNO2
• Molecular Weight: 218.05
• Hs Code.: 2933399090
• Mol file: 13445-16-4.mol

Synonyms:3-Bromo-2,6-dimethoxypyridine;

Chemical Property of 3-Bromo-2,6-dimethoxypyridine

Chemical Property:

• Vapor Pressure: 0.142mmHg at 25°C
• Refractive Index: 1.53
• Boiling Point: 223.6 °C at 760 mmHg
• PKA: -0.79±0.10(Predicted)
• Flash Point: 89 °C
• PSA: 31.35000
• Density: 1.484 g/cm³
• LogP: 1.86130
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

3-Bromo-2,6-dimethoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-2,6-dimethoxypyridine

There total 2 articles about 3-Bromo-2,6-dimethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,6-dimethoxypyridine (6231-18-1,122797-02-8) → 3-bromo-2,6-dimethoxypyridine (13445-16-4)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In diethyl ether; at 20 ℃; for 1h;

DOI:10.1021/acs.joc.1c02906

Reference yield: 76.0%

2,6-dimethoxypyridine (6231-18-1,122797-02-8) → 3-bromo-2,6-dimethoxypyridine (13445-16-4) + 3,5-dibromo-2,6-dimethoxypyridine (16727-44-9)

Guidance literature:

With bromine; In tetrachloromethane; at -40 - -30 ℃;

DOI:10.1016/j.bmcl.2009.02.091

Reference yield: 95.0%

3-bromo-2,6-dimethoxypyridine (13445-16-4) + chloro-diphenylphosphine (1079-66-9,74391-44-9) → 3-bromo-2,6-dimethoxy-4-diphenylphosphino-pyridine (220998-35-6)

Guidance literature:

3-bromo-2,6-dimethoxypyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

chloro-diphenylphosphine; In tetrahydrofuran; at -78 ℃;

DOI:10.1021/ja000163n

upstream raw materials:

2,6-dimethoxypyridine

Downstream raw materials:

(R)-2,6-dimethoxy-3-(p-tolylsulfinyl)pyridine

(S)-2,6-dimethoxy-3-(p-tolylsulfinyl)pyridine

3-Bromo-2,6-dimethoxy-4-di(p-methylphenyl)phosphinopyridine

3-bromo-2,6-dimethoxy-4-diphenylphosphino-pyridine

Refernces

• 1、 -. "AZACOUMARIN AND AZATHIOCOUMARIN DERIVATIVES FOR USE IN OPTICALLY ACTIVE DEVICES". Page/Page column 193-194. . Retrieved 2021/11/26.
• 2、 Ghosh, Indrajit,Khamrai, Jagadish,Savateev, Aleksandr,Shlapakov, Nikita,Antonietti, Markus,K?nig, Burkhard. "Organic semiconductor photocatalyst can bifunctionalize arenes and heteroarenes". . p. 360 - 366. Retrieved 2019/08/15.