Ethanone, 1-(3-hydroxy-2-pyridinyl)- (9CI)

Base Information

• Chemical Name: Ethanone, 1-(3-hydroxy-2-pyridinyl)- (9CI)
• CAS No.: 13210-29-2
• Molecular Formula: C7H7NO2
• Molecular Weight: 137.13598
• Hs Code.: 2933399990
• Mol file: 13210-29-2.mol

Synonyms:Ketone,3-hydroxy-2-pyridyl methyl (8CI);1-(3-Hydroxypyridin-2-yl)ethanone;2-Acetyl-3-hydroxypyridine;

Chemical Property of Ethanone, 1-(3-hydroxy-2-pyridinyl)- (9CI)

Chemical Property:

• Boiling Point: 311.545 °C at 760 mmHg
• PKA: 5.76±0.10(Predicted)
• Flash Point: 142.217 °C
• PSA: 50.19000
• Density: 1.218 g/cm³
• LogP: 0.98980
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(3-Hydroxypyridin-2-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(3-hydroxy-2-pyridinyl)- (9CI)

There total 13 articles about Ethanone, 1-(3-hydroxy-2-pyridinyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methylmagnesium bromide (75-16-1) + 3-hydroxypyridine-2-carbonitrile (932-35-4) → 1-(3-hydroxypyridin-2-yl)ethan-1-one (13210-29-2)

Guidance literature:

methylmagnesium bromide; 3-hydroxypyridine-2-carbonitrile; In tetrahydrofuran; at 20 ℃; for 0.5h; Ice cooling;

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield: 87.0%

3-hydroxypyridine-2-carboxylic acid (874-24-8) + methylmagnesium bromide (75-16-1) → 1-(3-hydroxypyridin-2-yl)ethan-1-one (13210-29-2)

Guidance literature:

3-hydroxypyridine-2-carboxylic acid; methylmagnesium bromide; With triethylamine; In tetrahydrofuran; at 64 ℃;

With hydrogenchloride; Methyl formate; In tetrahydrofuran; at 5 ℃;

DOI:10.1016/j.bmcl.2009.05.036

Reference yield: 77.0%

3-hydroxypyridine-2-carboxylic acid (874-24-8) + methylmagnesium chloride (676-58-4) → 1-(3-hydroxypyridin-2-yl)ethan-1-one (13210-29-2)

Guidance literature:

3-hydroxypyridine-2-carboxylic acid; methylmagnesium chloride; With triethylamine; In tetrahydrofuran; at 60 - 65 ℃; for 5h;

With Methyl formate; In tetrahydrofuran; at 5 - 20 ℃;

With hydrogenchloride; water; In tetrahydrofuran; at 10 ℃; pH=3 - 4;

upstream raw materials:

2-acetyl-3-ethoxypyridine

3-Methoxymethoxy-pyridine-2-carboxylic acid ethyl ester

ethyl acetate

3-hydroxypyridine-2-carboxylic acid

Downstream raw materials:

2-methyloxazolo<4,5-b>pyridine

3-methylisoxazolo<4,5-b>pyridine

2-acetyl-3-hydroxypyridine 1-oxide

2-methyloxazolo<4,5-b>pyridine 4-oxide

Refernces

• 1、 -. "EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO". Paragraph 0622; 0623. . Retrieved 2017/08/01.
• 2、 -. "TRICYCLIC SPIROCYCLE DERIVATIVES AND METHODS OF USE". Page/Page column 49. . Retrieved 2011/07/29.