L-Methionine-methyl-d3

Base Information

• Chemical Name: L-Methionine-methyl-d3
• CAS No.: 13010-53-2
• Molecular Formula: C5H8 D3 N O2 S
• Molecular Weight: 152.19
• Mol file: 13010-53-2.mol

Synonyms:Methionine-methyl-d3,L- (8CI)

Chemical Property of L-Methionine-methyl-d3

Chemical Property:

• Melting Point: 273 °C (dec.)(lit.)
• PSA: 88.62000
• LogP: 0.85170
• Storage Temp.: Refrigerator
• Solubility.: Aqueous Acid (Sparingly), Water (Slightly, Heated)

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-Methionine-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Labelled L-Methionine (M260440). Essential aminoacid for human development. Hepatoprotectant; antidote (acetominophen poisoning); urinary acidifier.

Technology Process of L-Methionine-methyl-d3

There total 8 articles about L-Methionine-methyl-d3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

iodomethane-d3 (865-50-9) + DL-homocysteine thiolactone hydrochloride (18265-50-4) → DL-methionine-methyl-2H3 (13010-53-2,284665-18-5,284665-20-9)

Guidance literature:

With sodium hydroxide; In ethanol; 1) room temp.; 2) reflux, 1 h;

DOI:10.1021/jo00194a014

Reference yield: 75.0%

C11H18(2)H3NO4S → L-2H3>methionine (13010-53-2,284665-18-5,284665-20-9)

Guidance literature:

With sulfuric acid; Reflux;

Reference yield:

C9H17(2)H3NO2S(1+)*C7H7O3S(1-) → L-2H3>methionine (13010-53-2,284665-18-5,284665-20-9)

Guidance literature:

DOI:10.1016/S0040-4039(00)89163-7

upstream raw materials:

iodomethane-d3

DL-homocysteine thiolactone hydrochloride

Downstream raw materials:

22-dihydrochondrillasterol

22-dihydro-25-dehydrochondrillasterol

Refernces

• 1、 Billington,Goldings. "". . p. 2937. Retrieved 1979.
• 2、 -. "Method for efficiently preparing deuterated iodomethane and application of deuterated iodomethane". Paragraph 0020-0033. . Retrieved 2021/08/07.
• 3、 Dippe,Brandt,Rost,Porzel,Schmidt,Wessjohann. "Rationally engineered variants of S-adenosylmethionine (SAM) synthase: Reduced product inhibition and synthesis of artificial cofactor homologues". supporting information. p. 3637 - 3640. Retrieved 2015/03/30.