(R)-N-(4-iodo)benzyl 2-N-(tert-butoxycarbonyl)amino-3-hydroxypropionamide

Base Information

• Chemical Name: (R)-N-(4-iodo)benzyl 2-N-(tert-butoxycarbonyl)amino-3-hydroxypropionamide
• CAS No.: 1192590-72-9
• Molecular Formula: C₁₅H₂₁IN₂O₄
• Molecular Weight: 420.247
• Mol file: 1192590-72-9.mol

Synonyms:(R)-N-(4-iodo)benzyl 2-N-(tert-butoxycarbonyl)amino-3-hydroxypropionamide

Chemical Property of (R)-N-(4-iodo)benzyl 2-N-(tert-butoxycarbonyl)amino-3-hydroxypropionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(4-iodo)benzyl 2-N-(tert-butoxycarbonyl)amino-3-hydroxypropionamide

There total 6 articles about (R)-N-(4-iodo)benzyl 2-N-(tert-butoxycarbonyl)amino-3-hydroxypropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(R)-N-tert-butoxycarbonyl serine (3262-72-4,3850-40-6,6368-20-3,90582-28-8,84311-18-2) + p-iodobenzylamine hydrochloride (59528-27-7) → (R)-N-(4-iodo)benzyl 2-N-(tert-butoxycarbonyl)amino-3-hydroxypropionamide (1192590-72-9)

Guidance literature:

(R)-N-tert-butoxycarbonyl serine; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

p-iodobenzylamine hydrochloride; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/jm9012054

Reference yield: 73.0%

→ (R)-N-(4-iodo)benzyl 2-N-(tert-butoxycarbonyl)amino-3-hydroxypropionamide (1192590-72-9)

Guidance literature:

Reference yield:

p-iodobenzylamine hydrochloride (59528-27-7) + C13H23NO7 → (R)-N-(4-iodo)benzyl 2-N-(tert-butoxycarbonyl)amino-3-hydroxypropionamide (1192590-72-9)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

upstream raw materials:

p-iodobenzylamine hydrochloride

(R)-N-tert-butoxycarbonyl serine

4-iodobenzyl chloride

2-(4-iodobenzyl)-isoindoline-1,3-dione

Downstream raw materials:

(R)-N-(4-iodo)benzyl 2-N-(tert-butoxycarbonyl)amino-3-methoxypropionamide

(R)-N-4'-(iodo)benzyl 2-acetamido-3-methoxypropionamide

(R)-N-4-(3-methoxyprop-1-ynyl)benzyl 2-acetamido-3-methoxypropionamide

(R)-N-4-(3-methoxypropyl)benzyl 2-acetamido-3-methoxypropionamide

Refernces

• 1、 -. "METHODS OF TREATMENT OF NEUROLOGICAL DISORDERS". Page/Page column 15. . Retrieved 2010/12/31.
• 2、 Ki, Duk Park,Morieux, Pierre,Salomé, Christophe,Cotten, Steven W.,Reamtong, Onrapak,Eyers, Claire,Gaskell, Simon J.,Stables, James P.,Liu, Rihe,Kohn, Harold. "Lacosamide isothiocyanate-based agents: Novel agents to target and identify lacosamide receptors". supporting information; experimental part. p. 6897 - 6911. Retrieved 2010/04/24.