4-Chloro-2-methyl-2-butanol

Base Information

• Chemical Name: 4-Chloro-2-methyl-2-butanol
• CAS No.: 1985-88-2
• Molecular Formula: C5H11ClO
• Molecular Weight: 122.595
• Mol file: 1985-88-2.mol

Synonyms:4-Chloro-2-methyl-2-butanol;

Chemical Property of 4-Chloro-2-methyl-2-butanol

Chemical Property:

• Vapor Pressure: 0.295mmHg at 25°C
• Refractive Index: 1.438
• Boiling Point: 178.6 °C at 760 mmHg
• PKA: 14.87±0.29(Predicted)
• Flash Point: 81.4 °C
• PSA: 20.23000
• Density: 1.021 g/cm³
• LogP: 1.38620
• Storage Temp.: 2-8°C
• Solubility.: Chloroform, Ethyl Acetate

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-2-methyl-2-butanol ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-2-methyl-2-butanol (cas# 1985-88-2) is a compound useful in organic synthesis.

Technology Process of 4-Chloro-2-methyl-2-butanol

There total 11 articles about 4-Chloro-2-methyl-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

methylmagnesium bromide (75-16-1) + ethyl 3-chloropropanoate (623-71-2) → 4-chloro-2-methyl-2-butanol (1985-88-2)

Guidance literature:

In tetrahydrofuran; diethyl ether; for 4h; Ambient temperature;

DOI:10.1021/jm00380a008

Reference yield: 60.0%

4-chloro-2-butanone (6322-49-2) + methyl magnesium iodide (917-64-6) + methylmagnesium chloride (676-58-4) + ethyl 3-chloropropanoate (623-71-2) + methyl vinyl ketone (78-94-4,25038-87-3) → 4-chloro-2-methyl-2-butanol (1985-88-2)

Guidance literature:

In diethyl ether; dichloromethane;

Reference yield:

2,5-dihypochloro-2,5-dimethylhexane (103603-61-8) → 4-chloro-2-methyl-2-butanol (1985-88-2) + 1,2-dichloro-ethane (107-06-2,52399-93-6) + acetone (67-64-1)

Guidance literature:

With Trichloroethylene; In tetrachloromethane; at 100 ℃; for 3h; Yield given;

DOI:10.1016/S0040-4039(00)89284-9

upstream raw materials:

methylmagnesium bromide

methyl 3-chloropropionate

1,3-dichloro-3-methylbutane

ethyl 3-chloropropanoate

Downstream raw materials:

N-prenylphthalimide

4-(4-bromo-3,5-dimethyl-phenoxy)-2-methyl-butan-2-ol

2-((S)-6-((R)-7-fluoro-4-(4-(3-hydroxy-3-methylbutoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

3-chloro-1,1-dimethyl-1-phenylpropane

Refernces

• 1、 Henry. "-". . . Retrieved 1906.
• 2、 -. "PROCESS AND INTERMEDIATES FOR PREPARING INDANYLOXYDIHYDROBENZOFURANYL ACETIC ACID DERIVATIVES AS GPR40 AGONISTS". Page/Page column 85; 86. . Retrieved 2015/04/15.
• 3、 Chorvat, Robert J.,Desai, Bipin N.,Radak, Suzanne Evans,McLaughlin, Kathleen T.,Miller, James E.,et al.. "22-Hydroxycholesterol Derivatives as HMG CoA Reductase Suppressors and Serum Cholesterol Lowering Agents". . p. 194 - 200. Retrieved 2007/10/02.