Technology Process of 3-(4-([3,4'-bipyridin]-2-yloxy)phenyl)-6-chloro-1-methyl-1H-pyrrolo[3,2-b]pyridine
There total 4 articles about 3-(4-([3,4'-bipyridin]-2-yloxy)phenyl)-6-chloro-1-methyl-1H-pyrrolo[3,2-b]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
dimethyl sulfoxide;
at 80 ℃;
for 12h;
Inert atmosphere;
Schlenk technique;
DOI:10.1016/j.bmcl.2014.06.028
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere; Schlenk technique
1.2: 1 h / 20 °C / Inert atmosphere; Schlenk technique
2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere; Schlenk technique
3.1: caesium carbonate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere; Schlenk technique
With
tetrakis(triphenylphosphine) palladium(0); sodium hydride; potassium carbonate; caesium carbonate;
In
water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
2.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.06.028
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere; Schlenk technique
2: caesium carbonate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere; Schlenk technique
With
tetrakis(triphenylphosphine) palladium(0); potassium carbonate; caesium carbonate;
In
water; dimethyl sulfoxide; N,N-dimethyl-formamide;
1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.06.028