Ethyl 2-Hydroxy-4-fluorobenzoate

Base Information

• Chemical Name: Ethyl 2-Hydroxy-4-fluorobenzoate
• CAS No.: 1737-21-9
• Molecular Formula: C9H9 F O3
• Molecular Weight: 184.167
• Hs Code.: 2918290000
• Mol file: 1737-21-9.mol

Synonyms:Salicylicacid, 4-fluoro-, ethyl ester (7CI,8CI); 4-Fluoro-2-hydroxybenzoic acid ethylester

Chemical Property of Ethyl 2-Hydroxy-4-fluorobenzoate

Chemical Property:

• Vapor Pressure: 0.022mmHg at 25°C
• Refractive Index: 1.52
• Boiling Point: 242.581°C at 760 mmHg
• PKA: 8.93±0.10(Predicted)
• Flash Point: 100.51°C
• PSA: 46.53000
• Density: 1.257g/cm³
• LogP: 1.70800
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Ethyl 4-fluoro-2-hydroxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-Hydroxy-4-fluorobenzoate

There total 5 articles about Ethyl 2-Hydroxy-4-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethanol (64-17-5) + 4-fluorosalicylic acid (345-29-9) → 4-fluoro-2-hydroxybenzoic acid ethyl ester (1737-21-9)

Guidance literature:

With sulfuric acid; at 120 ℃;

Reference yield: 71.0%

4-fluorobenzoic acid ethyl ester (451-46-7) → 4-fluoro-2-hydroxybenzoic acid ethyl ester (1737-21-9)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; Selectfluor; trifluoroacetic acid; trifluoroacetic anhydride; at 110 ℃; for 14h;

DOI:10.1021/ol301104n

Reference yield:

4-fluorosalicylic acid (345-29-9) + ethyl iodide (75-03-6) → 4-fluoro-2-hydroxybenzoic acid ethyl ester (1737-21-9)

Guidance literature:

With sodium acetate; In N-methyl-acetamide;

upstream raw materials:

ethanol

4-fluorosalicylic acid

4-Aminosalicylic acid

ethyl iodide

Downstream raw materials:

4-fluoro-2-methoxybenzoic acid ethyl ester

Refernces

• 1、 -. "Boron-Containing Small Molecules as Anti-Inflammatory Agents". Paragraph 0757. . Retrieved 2015/11/16.
• 2、 -. "(AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES". Page/Page column 21. . Retrieved 2009/12/27.