3,6-Dimethoxyxanthone

Base Information

• Chemical Name: 3,6-Dimethoxyxanthone
• CAS No.: 1214-24-0
• Molecular Formula: C13H8 O4
• Molecular Weight: 228.204
• Hs Code.: 2932999099
• Mol file: 1214-24-0.mol

Synonyms:Xanthen-9-one,3,6-dihydroxy- (7CI,8CI); 3,6-Dihydroxy-9H-xanthen-9-one;3,6-Dihydroxyxanthen-9-one; 3,6-Dihydroxyxanthone

Chemical Property of 3,6-Dimethoxyxanthone

Chemical Property:

• Melting Point: 350°C (rough estimate)
• Refractive Index: 1.4977 (estimate)
• Boiling Point: 330°C (rough estimate)
• PKA: 7.18±0.20(Predicted)
• PSA: 70.67000
• Density: 1.3036 (rough estimate)
• LogP: 2.35740

Purity/Quality:

98%Min ^*data from raw suppliers

3,6-Dihydroxy-xanthen-9-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,6-Dihydroxy-xanthen-9-one is used in preparation method of Heterocyclic compounds and application in the preparation of Lanreotide.

Technology Process of 3,6-Dimethoxyxanthone

There total 37 articles about 3,6-Dimethoxyxanthone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,2',4,4'-tetrahydroxybenzophenone (131-55-5) → 3,6-dihydroxy-xanthen-9-one (1214-24-0)

Guidance literature:

In water monomer; at 220 ℃; under 1900 Torr;

DOI:10.1016/j.tet.2004.06.108

Reference yield: 91.0%

3,6-dimethoxy-9H-xanthen-9-one (15007-07-5) → 3,6-dihydroxy-xanthen-9-one (1214-24-0)

Guidance literature:

With hydrogen iodide; phenol; at 160 ℃; for 8h;

DOI:10.1002/jps.2600820103

Reference yield: 81.5%

4-hydroxysalicylic acid (89-86-1) + recorcinol (108-46-3) → 3,6-dihydroxy-xanthen-9-one (1214-24-0)

Guidance literature:

With zinc(II) chloride; trichlorophosphate; at 75 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.ejmech.2017.03.068

upstream raw materials:

2,2',4,4'-tetrahydroxybenzophenone

3,6-dimethoxy-9H-xanthen-9-one

methyl 2,4-dihydroxybenzoate

recorcinol

Downstream raw materials:

3,6-dihydroxy-4,5-bis-morpholin-4-ylmethyl-xanthen-9-one

6-Hydroxy-3H-xanthen-3-one

3,6-dihydroxyxanthane

3,6-bis-(4'-(4''-chlorobenzoyl)phenoxy)xanthone

Refernces

• 1、 Correia-Da-Silva, Marta,Sousa, Emília,Duarte, Bárbara,Marques, Franklim,Carvalho, Félix,Cunha-Ribeiro, Luís M.,Pinto, Madalena M. M.. "Polysulfated xanthones: Multipathway development of a new generation of dual anticoagulant/antiplatelet agents". . p. 5373 - 5384. Retrieved 2011.
• 2、 Antony, Lovely Angel Panamparambil,Slanina, Tomas,Sebej, Peter,Solomek, Tomas,Klan, Petr. "Fluorescein analogue xanthene-9-carboxylic acid: A transition-metal-free CO releasing molecule activated by green light". . p. 4552 - 4555. Retrieved 2013.
• 3、 Pomerantz et al.. "-". . p. 2183,2189. Retrieved 1972.
• 4、 Shankar, Brajesh,Das, Aparoop,Parida, Pratap. "Design, molecular docking study and synthesis of 3,6-bis(3'-substituted propoxy)xanthone derivatives as COX-2 inhibitors". . p. 4634 - 4640. Retrieved 2015.
• 5、 Pinto, Eugenia,Afonso, Carlos,Duarte, Serafim,Vale-Silva, Luis,Costa, Elisangela,Sousa, Emilia,Pinto, Madalena. "Antifungal Activity of Xanthones: Evaluation of their Effect on Ergosterol Biosynthesis by High-performance Liquid Chromatography". . p. 212 - 222. Retrieved 2011.
• 6、 Liu, Chaomei,Zhang, Mei,Zhang, Zhenhuan,Zhang, Steven B.,Yang, Shanmin,Zhang, Amy,Yin, Liangjie,Swarts, Steven,Vidyasagar, Sadasivan,Zhang, Lurong,Okunieff, Paul. "Synthesis and anticancer potential of novel xanthone derivatives with 3,6-substituted chains". . p. 4263 - 4271. Retrieved 2016.
• 7、 Syahri, Jufrizal,Yuanita, Emmy,Nurohmah, Beta Achromi,Wathon, Muhammad Hizbul,Syafri, Rahmadini,Armunanto, Ria,Purwono, Bambang. "Xanthone as antimalarial: QSAR analysis, synthesis, molecular docking and in-vitro antimalarial evaluation". . p. 29 - 40. Retrieved 2017.
• 8、 Maity, Debabrata,Sarkar, Bidyut,Maiti, Sudipta,Govindaraju. "A highly selective reaction-based two-photon probe for Copper(I) in aqueous media". . p. 785 - 788. Retrieved 2013.
• 9、 Zhang, Xiao-Jin,Ye, Suo-Fu,Zhang, Yu,Meng, Hu-Yan,Zhang, Ming-Qian,Gao, Wen-Lei,You, Qi-Dong. "Microwave-assisted efficient and green synthesis of hydroxyxanthone in water". . p. 2952 - 2958. Retrieved 2012.
• 10、 Dong, Bin,Gao, Shi,Ma, Bin,Wang, Xuefeng,You, Lijuan,Zuo, Guomin. "Optical detection of sulfur mustard contaminated surfaces based on a sprayable fluorescent probe". supporting information. p. 20569 - 20574. Retrieved 2021/11/27.