2-[2-(Dimethylamino)ethoxy]aniline

Base Information

• Chemical Name: 2-[2-(Dimethylamino)ethoxy]aniline
• CAS No.: 1202-00-2
• Molecular Formula: C10H16N2O
• Molecular Weight: 180.25
• Hs Code.: 2922199090
• European Community (EC) Number: 873-994-4
• DSSTox Substance ID: DTXSID40424468
• Wikidata: Q82237058
• Mol file: 1202-00-2.mol

Synonyms:1202-00-2;2-[2-(dimethylamino)ethoxy]aniline;2-(2-Dimethylamino-ethoxy)-phenylamine;2-(2-(Dimethylamino)ethoxy)aniline;Benzenamine, 2-[2-(dimethylamino)ethoxy]-;2-[2-(DIMETHYLAMINO)ETHOXY]ANILINE DIHYDROCHLORIDE;SCHEMBL3893843;DTXSID40424468;OHDPNHWSANKRNF-UHFFFAOYSA-N;BAA20200;BBL036985;MFCD08144113;STL560011;AKOS000100433;VS-13815;CS-0308735;FT-0633476;EN300-1294995;Z239127504

Chemical Property of 2-[2-(Dimethylamino)ethoxy]aniline

Chemical Property:

• Vapor Pressure: 0.00219mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 289.5 °C at 760 mmHg
• PKA: 8?+-.0.28(Predicted)
• Flash Point: 128.9 °C
• PSA: 38.49000
• Density: 1.044 g/cm³
• LogP: 1.79040
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 180.126263138
• Heavy Atom Count: 13
• Complexity: 139

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(2-Dimethylamino-ethoxy)phenylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCOC1=CC=CC=C1N

Technology Process of 2-[2-(Dimethylamino)ethoxy]aniline

There total 6 articles about 2-[2-(Dimethylamino)ethoxy]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-[2(N,N-dimethylamino)ethyl]oxy-2-nitro-benzene (51736-38-0) → 2-(2'-aminophenoxy)-1-(N,N-dimethylamino)-ethane (1202-00-2)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 50 ℃; for 2h;

Reference yield:

2-hydroxynitrobenzene (88-75-5,78813-12-4) → 2-(2'-aminophenoxy)-1-(N,N-dimethylamino)-ethane (1202-00-2)

Guidance literature:

Reference yield:

2-(2-nitrophenoxy)-1-mesyloxyethane (850895-60-2) → 2-(2'-aminophenoxy)-1-(N,N-dimethylamino)-ethane (1202-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: 10% Pd/C; hydrogen / ethanol

With 10% Pd/C; hydrogen; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.09.035

upstream raw materials:

2-hydroxynitrobenzene

2-(2-hydroxyethoxy)nitrobenzene

2-(2-nitrophenoxy)-1-mesyloxyethane

ortho-nitrofluorobenzene

Downstream raw materials:

C₂₆H₃₁FN₄O₂

4-(1-benzyl-1H-pyrazol-4-yl)-N-(2-(2-(dimethylamino)ethoxy)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamide

4-bromo-N-(2-(2-(dimethylamino)ethoxy)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamide

4-{2-[2-(dimethylamino)ethoxy]phenyl}-10-oxa-4-azatricyclo[5.2.1]decane-3,5-dione

Refernces

• 1、 -. "COUMARIN DERIVATIVES AND METHODS OF USE IN TREATING HYPERPROLIFERATIVE DISEASES". . . Retrieved 2014/10/04.
• 2、 -. "Substituted alkylamine derivatives and methods of use". Page 81. . Retrieved 2010/02/05.