4H-Pyran-4-one,3-methoxy-(6CI,7CI,8CI,9CI)

Base Information

• Chemical Name: 4H-Pyran-4-one,3-methoxy-(6CI,7CI,8CI,9CI)
• CAS No.: 1193-64-2
• Molecular Formula: C6H6 O3
• Molecular Weight: 126.112
• Hs Code.: 2932999099
• Mol file: 1193-64-2.mol

Synonyms:3-Methoxy-4-pyranone;3-O-Methyl pyromeconate

Chemical Property of 4H-Pyran-4-one,3-methoxy-(6CI,7CI,8CI,9CI)

Chemical Property:

• PSA: 39.44000
• LogP: 0.64840

Purity/Quality:

98%,99%, ^*data from raw suppliers

PyromeconicAcidO-MethylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Pyromeconic Acid O-Methyl Ether is used in the synthesis of the derivative (Arecolidine) of Arecoline (A767500), a cholinergic alkaloid from seeds of the betel nut palm Areca catechu. Anthelmintic (Cestodes); cathartic.

Technology Process of 4H-Pyran-4-one,3-methoxy-(6CI,7CI,8CI,9CI)

There total 10 articles about 4H-Pyran-4-one,3-methoxy-(6CI,7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-hydroxy-pyran-4-one (496-63-9) + methyl iodide (74-88-4) → 3-methoxy-4H-pyran-4-one (1193-64-2)

Guidance literature:

With potassium carbonate; In acetonitrile; at 50 ℃; for 24h;

Reference yield: 45.0%

5-methoxy-4-oxo-4H-pyran-2-carboxylic acid (1199-60-6) → 3-methoxy-4H-pyran-4-one (1193-64-2)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; for 4h; Reflux;

DOI:10.1016/j.ejmech.2016.03.014

Reference yield: 23.6%

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one (501-30-4,123712-78-7) + methyl iodide (74-88-4) → 3-methoxy-4H-pyran-4-one (1193-64-2)

Guidance literature:

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one; methyl iodide; With potassium carbonate; In acetone; for 3h; Reflux;

With Jones reagent; In acetone; for 0.666667h; Reflux;

In 1-methyl-pyrrolidin-2-one; for 4h; Reflux;

upstream raw materials:

diazomethane

3-hydroxy-pyran-4-one

Pyran-3,4-dion

methyl iodide

Downstream raw materials:

3-methoxy-4(1H)-pyridone

formic acid

Methoxyacetone

Refernces

• 1、 Bai, Renren,Gu, Jinping,Guo, Jianan,Jiang, Xiaoying,Lv, Yangjing,Mi, Zhisheng,Shi, Yuan,Xie, Yuanyuan,Yao, Chuansheng,Zhang, Changjun,Zhou, Tao. "Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity". . . Retrieved 2020/05/22.
• 2、 Xie, Yuan-Yuan,Lu, Zidong,Kong, Xiao-Le,Zhou, Tao,Bansal, Sukhi,Hider, Robert. "Systematic comparison of the mono-, dimethyl-and trimethyl 3-hydroxy-4(1H)-pyridones-Attempted optimization of the orally active iron chelator, deferiprone". . p. 132 - 140. Retrieved 2016/04/05.