10-Hydroxynortriptyline

Base Information

• Chemical Name: 10-Hydroxynortriptyline
• CAS No.: 1156-99-6
• Molecular Formula: C19H21 N O
• Molecular Weight: 279.382
• UNII: 7A43OTR1B8,DQQ770F8UO,411I184MG3
• Nikkaji Number: J346.736H
• ChEMBL ID: CHEMBL3638287
• Mol file: 1156-99-6.mol

Synonyms:10-hydroxynortriptyline;10-hydroxynortriptyline hydrochloride;10-hydroxynortriptyline maleate (1:1);10-hydroxynortriptyline, (+-)-isomer;10-hydroxynortriptyline, (E)-isomer;10-hydroxynortriptyline, (Z)-isomer

Chemical Property of 10-Hydroxynortriptyline

Chemical Property:

• Vapor Pressure: 2.42E-09mmHg at 25°C
• Boiling Point: 462.3°Cat760mmHg
• Flash Point: 142.1°C
• PSA: 32.26000
• Density: 1.164g/cm³
• LogP: 3.70820
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 279.162314293
• Heavy Atom Count: 21
• Complexity: 365

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCCC=C1C2=CC=CC=C2CC(C3=CC=CC=C31)O
• Isomeric SMILES: CNCC/C=C\1/C2=CC=CC=C2CC(C3=CC=CC=C31)O

Technology Process of 10-Hydroxynortriptyline

There total 2 articles about 10-Hydroxynortriptyline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

amitriptyline hydrochloride (549-18-8,8058-15-9) → 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine (72-69-5) + 10-Hydroxynortriptyline (1156-99-6) + (Z)-10-Hydroxyamitriptyline (64520-05-4)

Guidance literature:

With glucose dehydrogenase; D-glucose; cytochrome P_450BM3 F₈₇A/H₁₇₁L/Q₃₀₇H/N₃₁₉Y mutant; oxygen; β-nicotinamide adenine dinucleotide phosphate sodium salt; In ethanol; at 25 ℃; for 2h; pH=8.5; Enzymatic reaction;

DOI:10.1002/chem.201502020

Reference yield:

→ 10-Hydroxynortriptyline (1156-99-6)

Guidance literature:

5-<3-Methylamino-propyliden>-5H-dibenzocyclohepten, 1.) Diboran, 2.) H2O2, NaOH, 3.) KIO3;

upstream raw materials:

amitriptyline hydrochloride

Refernces