2,3-Dihydro-1H-benz[de]isoquinoline

Base Information

• Chemical Name: 2,3-Dihydro-1H-benz[de]isoquinoline
• CAS No.: 22817-26-1
• Molecular Formula: C12H11N
• Molecular Weight: 169.226
• Hs Code.: 2933990090
• Mol file: 22817-26-1.mol

Synonyms:2,3-Dihydro-1H-benzo[de]isoquinoline;

Chemical Property of 2,3-Dihydro-1H-benz[de]isoquinoline

Chemical Property:

• Vapor Pressure: 0.000125mmHg at 25°C
• Melting Point: 100-102 °C
• Refractive Index: 1.661
• Boiling Point: 334.8 °C at 760 mmHg
• PKA: 8.32±0.20(Predicted)
• Flash Point: 171.2 °C
• PSA: 12.03000
• Density: 1.138 g/cm³
• LogP: 2.77180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dihydro-1H-benzo[de]isoquinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R34:Causes burns.
• Hazard Codes: R34:Causes burns.
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Dihydro-1H-benz[de]isoquinoline

There total 5 articles about 2,3-Dihydro-1H-benz[de]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,3-dihydro-(2-phenylmethyl)-1H-benz[de]isoquinoline (65448-54-6) → 2,3-dihydro-1H-benzo[de]isoquinoline (22817-26-1)

Guidance literature:

2,3-dihydro-(2-phenylmethyl)-1H-benz[de]isoquinoline; With chloroformic acid ethyl ester; In dichloromethane; for 8h; Heating;

With potassium hydroxide; hydrazine; In ethylene glycol; for 4h; Heating;

DOI:10.1021/ja029236o

Reference yield: 61.0%

1,8-Naphthalimide (81-83-4) → 2,3-dihydro-1H-benzo[de]isoquinoline (22817-26-1)

Guidance literature:

With hydrazine hydrate; potassium hydroxide; In 1,2-dimethoxyethane; at 180 ℃; for 24h;

Reference yield:

N-benzyl-1,8-naphthalimide (2896-24-4) → 2,3-dihydro-1H-benzo[de]isoquinoline (22817-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: AlH₃; LiAlH₄ / tetrahydrofuran / 15.5 h / 20 - 40 °C

1.2: HCl / tetrahydrofuran / 1 h

1.3: 89 percent / aq. KOH / tetrahydrofuran / pH 14

2.1: ethyl chloroformate / CH₂Cl₂ / 8 h / Heating

2.2: 89 percent / KOH; H₂NNH₂ / ethane-1,2-diol / 4 h / Heating

With aluminium hydride; lithium aluminium tetrahydride; chloroformic acid ethyl ester; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja029236o

upstream raw materials:

1,8-Naphthalimide

2,3-dihydro-(2-phenylmethyl)-1H-benz[de]isoquinoline

N-benzyl-1,8-naphthalimide

1,8-Naphthalic anhydride

Downstream raw materials:

N-(4-Methoxy-phenyl)-1H,3H-benzo[de]isoquinoline-2-carboxamidine

1,3-Dihydro-2-((4-(4-fluorophenyl)-4-oxobutyl))-1H-benz[de] isoquinoline

8-(2,3-Dihydro-1H-benzo[de]isoquinolin-2-ylmethyl)-5-(3,4-dimethoxybenzylamino)-2-(2-furyl)[1,2,4]triazolo[1,5-c]pyrimidine

Refernces

• 1、 -. "COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT COMPRISING THE SAME, AND ELECTRONIC DEVICE THEREOF". Paragraph 0125-0127. . Retrieved 2018/12/01.
• 2、 -. "5-HT7 receptor antagonists". . . Retrieved 2008/06/13.