Technology Process of 7-Amino-2-[2-(4-methyl-cyclohexyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
There total 27 articles about 7-Amino-2-[2-(4-methyl-cyclohexyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonium hydroxide;
In
ethanol;
for 5.5h;
Ambient temperature;
DOI:10.1248/cpb.40.2391
- Guidance literature:
-
Multi-step reaction with 10 steps
1: NaH / benzene
2: H2 / 5percent Pd/C / ethanol / 760 Torr
3: 94.5 percent / LiAlH4 / tetrahydrofuran
4: 64.2 percent / PBr3 / diethyl ether; diethyl ether / 16 h / Ambient temperature
5: dimethylsulfoxide
6: 16.7 percent / CF3COOH
7: 35 percent / heptane / 2 h / 140 - 150 °C
8: 90 percent / fuming HNO3, AcOH / 2.5 h / Ambient temperature
9: 100 percent / tripropylamine, POCl3 / 3 h / 80 - 85 °C
10: 69 percent / concd. NH4OH / ethanol / 5.5 h / Ambient temperature
With
tri-n-propylamine; ammonium hydroxide; lithium aluminium tetrahydride; hydrogen; nitric acid; phosphorus tribromide; sodium hydride; acetic acid; trifluoroacetic acid; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; n-heptane; dimethyl sulfoxide; benzene;
DOI:10.1248/cpb.40.2391
- Guidance literature:
-
Multi-step reaction with 9 steps
1: H2 / 5percent Pd/C / ethanol / 760 Torr
2: LiAlH4 / tetrahydrofuran
3: PBr3 / diethyl ether; diethyl ether / 16 h / Ambient temperature
4: dimethylsulfoxide
5: 16.7 percent / CF3COOH
6: 35 percent / heptane / 2 h / 140 - 150 °C
7: 90 percent / fuming HNO3, AcOH / 2.5 h / Ambient temperature
8: 100 percent / tripropylamine, POCl3 / 3 h / 80 - 85 °C
9: 69 percent / concd. NH4OH / ethanol / 5.5 h / Ambient temperature
With
tri-n-propylamine; ammonium hydroxide; lithium aluminium tetrahydride; hydrogen; nitric acid; phosphorus tribromide; acetic acid; trifluoroacetic acid; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; n-heptane; dimethyl sulfoxide;
DOI:10.1248/cpb.40.2391