Technology Process of (3R,5S)-3,5-O-benzylidene-6-oxohexanoic acid
There total 5 articles about (3R,5S)-3,5-O-benzylidene-6-oxohexanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3R,5S)-3,5-O-benzylidene-1-trimethylsiloxycyclohex-1-ene;
With
ozone;
In
dichloromethane;
at -78 ℃;
With
triphenylphosphine;
In
dichloromethane;
at -78 - 20 ℃;
for 1h;
DOI:10.1248/cpb.48.1545
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 70 percent / BH3*THF / tetrahydrofuran; hexamethylphosphoric acid triamide / 60 h / -15 °C
2.1: 70 percent / triacetoxy periodinane / CH2Cl2 / 0.25 h / 0 °C
3.1: 75 percent / lithium (S,S)-α,α'-dimethylbenzylamide / tetrahydrofuran; hexane / 0.17 h / -100 °C
4.1: O3 / CH2Cl2 / -78 °C
4.2: 85 percent / PPh3 / CH2Cl2 / 1 h / -78 - 20 °C
With
borane-THF; Dess-Martin periodane; lithium (S,S)-bis(α-methylbenzyl)amide; ozone;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;
DOI:10.1248/cpb.48.1545
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 100 percent / BF3*Et2O / CH2Cl2 / 20 °C
2.1: 70 percent / BH3*THF / tetrahydrofuran; hexamethylphosphoric acid triamide / 60 h / -15 °C
3.1: 70 percent / triacetoxy periodinane / CH2Cl2 / 0.25 h / 0 °C
4.1: 75 percent / lithium (S,S)-α,α'-dimethylbenzylamide / tetrahydrofuran; hexane / 0.17 h / -100 °C
5.1: O3 / CH2Cl2 / -78 °C
5.2: 85 percent / PPh3 / CH2Cl2 / 1 h / -78 - 20 °C
With
borane-THF; boron trifluoride diethyl etherate; Dess-Martin periodane; lithium (S,S)-bis(α-methylbenzyl)amide; ozone;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane;
DOI:10.1248/cpb.48.1545