5-METHOXYPICOLINALDEHYDE

Base Information

• Chemical Name: 5-METHOXYPICOLINALDEHYDE
• CAS No.: 22187-96-8
• Molecular Formula: C7H7NO2
• Molecular Weight: 137.138
• Hs Code.: 2933399090
• Mol file: 22187-96-8.mol

Synonyms:Picolinaldehyde,5-methoxy- (8CI);5-Methoxy-2-formylpyridine;5-Methoxy-2-pyridinecarbaldehyde;5-Methoxypyridine-2-carboxaldehyde;

Chemical Property of 5-METHOXYPICOLINALDEHYDE

Chemical Property:

• Vapor Pressure: 0.024mmHg at 25°C
• Refractive Index: 1.551
• Boiling Point: 248.375 °C at 760 mmHg
• PKA: 3.16±0.10(Predicted)
• Flash Point: 104.014 °C
• PSA: 39.19000
• Density: 1.159 g/cm³
• LogP: 0.90270
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Methoxypicolinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHOXYPICOLINALDEHYDE

There total 13 articles about 5-METHOXYPICOLINALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-hydroxymethyl-5-methoxypyridine (127978-70-5) → 5-methoxy-2-pyridinecarboxaldehyde (22187-96-8)

Guidance literature:

With manganese(IV) oxide; In chloroform; at 20 ℃; for 18h;

DOI:10.1016/S0957-4166(01)00186-0

Reference yield: 66.1%

5-fluoropicolinaldehyde (31181-88-1) + sodium methylate (124-41-4) → 5-methoxy-2-pyridinecarboxaldehyde (22187-96-8)

Guidance literature:

In methanol; at 55 ℃;

Reference yield:

5-Hydroxy-2-methylpyridine (1121-78-4) → 5-methoxy-2-pyridinecarboxaldehyde (22187-96-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 75 percent / sodium hydride / dimethylformamide / 4 h / 20 °C

2: 35 percent / H₂O₂; acetic acid / H₂O / 5 h / 100 °C

3: CH₂Cl₂ / 0 - 20 °C

4: 573 mg / CH₂Cl₂; methanol / 5 h / Heating

5: 60 percent / manganase dioxide / CH₂Cl₂ / 0.5 h / 20 °C

With manganase dioxide; dihydrogen peroxide; sodium hydride; acetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.07.065

upstream raw materials:

2-hydroxymethyl-5-methoxypyridine

1-(1-Benzyl-1H-indol-3-yl)-1-(5-methoxypyridin-2-yl)-methanol

5-Hydroxy-2-methylpyridine

5-methoxy-2-picoline

Downstream raw materials:

(S)-(+)-N-[(1E)-(5-methoxy-2-pyridinyl)methylidene]-4-methylbenzenesulfinamide

2-hydroxymethyl-5-methoxypyridine

Refernces

• 1、 -. "MELANOCORTIN TYPE 4 RECEPTOR AGONIST PIPERIDINOYLPYRROLIDINES". Page/Page column 61-62. . Retrieved 2008/06/13.
• 2、 Hatanaka, Masashi,Takahashi, Kyoko,Nakamura, Shigeo,Mashino, Tadahiko. "Preparation and antioxidant activity of α-pyridoin and its derivatives". . p. 6763 - 6770. Retrieved 2007/10/03.