2-Hydrazinyl-5-methyl-3-nitropyridine

Base Information

• Chemical Name: 2-Hydrazinyl-5-methyl-3-nitropyridine
• CAS No.: 21901-25-7
• Molecular Formula: C6H8N4O2
• Molecular Weight: 168.155
• Hs Code.: 2933990090
• Mol file: 21901-25-7.mol

Synonyms:3-Picoline, 6-hydrazino-5-nitro- (6CI,8CI);2(1H)-Pyridinone,5-methyl-3-nitro-, hydrazone (9CI);

Chemical Property of 2-Hydrazinyl-5-methyl-3-nitropyridine

Chemical Property:

• Boiling Point: 342.6 °C at 760 mmHg
• Flash Point: 161 °C
• PSA: 96.76000
• Density: 1.432 g/cm³
• LogP: 1.88030
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Hydrazinyl-5-methyl-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Hydrazinyl-5-methyl-3-nitropyridine

There total 4 articles about 2-Hydrazinyl-5-methyl-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-5-methyl-3-nitro-pyridine (23056-40-8) → 3-nitro-5-methyl-2-hydrazine-pyridine (21901-25-7)

Guidance literature:

With ethanol; hydrazine hydrate;

DOI:10.1021/ja01641a016

Reference yield:

2-hydroxy-5-methyl-3-nitropyridine (7464-14-4) → 3-nitro-5-methyl-2-hydrazine-pyridine (21901-25-7)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus (V)-chloride; phosphoryl chloride

2: ethanol; N₂H₄+H₂O

With ethanol; phosphorus pentachloride; hydrazine hydrate; trichlorophosphate;

DOI:10.1021/ja01641a016

Reference yield:

5-methyl-pyridin-2-ol (1003-68-5,91914-06-6) → 3-nitro-5-methyl-2-hydrazine-pyridine (21901-25-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / water / 18 h / 60 °C

2: thionyl chloride / N,N-dimethyl-formamide / 3 h / 110 °C

3: hydrazine hydrate / methanol / 12 h / 80 °C

With thionyl chloride; sulfuric acid; nitric acid; hydrazine hydrate; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.03.119

upstream raw materials:

2-chloro-5-methyl-3-nitro-pyridine

2-hydroxy-5-methyl-3-nitropyridine

5-methyl-pyridin-2-ol

Downstream raw materials:

C₁₆H₁₉N₅O

C₁₆H₁₈N₄O₃

C₂₁H₂₇N₅O₃

C₂₁H₂₆N₄O₅

Refernces