Ethanone, 1-(3,4-dimethyl-1H-pyrrol-2-yl)- (9CI)

Base Information

• Chemical Name: Ethanone, 1-(3,4-dimethyl-1H-pyrrol-2-yl)- (9CI)
• CAS No.: 2169-18-8
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.181
• Mol file: 2169-18-8.mol

Synonyms:Ketone,3,4-dimethylpyrrol-2-yl methyl (7CI,8CI)

Chemical Property of Ethanone, 1-(3,4-dimethyl-1H-pyrrol-2-yl)- (9CI)

Chemical Property:

• PSA: 32.86000
• LogP: 1.83410

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(3,4-dimethyl-1H-pyrrol-2-yl)- (9CI)

There total 5 articles about Ethanone, 1-(3,4-dimethyl-1H-pyrrol-2-yl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(ethoxycarbonyl)-3,4,5-trimethylpyrrole (2199-46-4) → 2-Acetyl-3,4-dimethyl-pyrrol (2169-18-8)

Guidance literature:

Multi-step reaction with 3 steps

1: SO₂Cl₂; diethyl ether / Erwaermen des Reaktionsprodukts mit H₂O

2: aqueous KOH-solution

3: diethyl ether / und Erwaermen des Reaktionsgemisches mit Acetylbromid

With potassium hydroxide; sulfuryl dichloride; diethyl ether;

Reference yield:

ethyl 3,5-dimethyl-4-formyl-1H-pyrrole-2-carboxylate (2199-64-6) → 2-Acetyl-3,4-dimethyl-pyrrol (2169-18-8)

Guidance literature:

Multi-step reaction with 4 steps

1: Raney nickel; ethanol / 160 °C / 110326 Torr / Hydrogenation

2: SO₂Cl₂; diethyl ether / Erwaermen des Reaktionsprodukts mit H₂O

3: aqueous KOH-solution

4: diethyl ether / und Erwaermen des Reaktionsgemisches mit Acetylbromid

With potassium hydroxide; sulfuryl dichloride; diethyl ether; ethanol; nickel;

Reference yield:

5-ethoxycarbonyl-3,4-dimethylpyrrole-2-carboxylic acid (85057-78-9) → 2-Acetyl-3,4-dimethyl-pyrrol (2169-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous KOH-solution

2: diethyl ether / und Erwaermen des Reaktionsgemisches mit Acetylbromid

With potassium hydroxide; diethyl ether;

upstream raw materials:

3,4-dimethyl-1H-pyrrole

ethylmagnesium bromide

2-(ethoxycarbonyl)-3,4,5-trimethylpyrrole

ethyl 3,5-dimethyl-4-formyl-1H-pyrrole-2-carboxylate