4-PHENOXYPHENYLMAGNESIUM BROMIDE

Base Information

• Chemical Name: 4-PHENOXYPHENYLMAGNESIUM BROMIDE
• CAS No.: 21473-02-9
• Molecular Formula: C12H9BrMgO
• Molecular Weight: 273.412
• Hs Code.: 29310099
• Mol file: 21473-02-9.mol

Synonyms:4-Benzyloxyphenylmagnesium bromide solution;

Chemical Property of 4-PHENOXYPHENYLMAGNESIUM BROMIDE

Chemical Property:

• Boiling Point: 65 °C
• Flash Point: <1 °F
• PSA: 9.23000
• Density: 0.968 g/mL at 25 °C
• LogP: 4.12470
• Storage Temp.: 2-8°C
• Sensitive.: Air & Moisture Sensitive
• Water Solubility.: It reacts with water.

Purity/Quality:

98%Min ^*data from raw suppliers

4-Phenoxyphenylmagnesium bromide solution 0.5M in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F;C
• Hazard Codes: F,C,Xn
• Statements: 11-19-22-34-40-36/37
• Safety Statements: 16-23-26-36/37/39-45-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Phenoxyphenylmagnesium bromide is used as an organic chemical synthesis intermediate.

Technology Process of 4-PHENOXYPHENYLMAGNESIUM BROMIDE

There total 3 articles about 4-PHENOXYPHENYLMAGNESIUM BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

→ 4-phenoxyphenylmagnesium bromide (21473-02-9) + N-tert-Butyloxycarbonyl-4-hydroxy-4-(4-phenoxyphenyl)piperidine (171350-04-2)

Guidance literature:

Reference yield:

4-Bromodiphenyl ether (101-55-3) → 4-phenoxyphenylmagnesium bromide (21473-02-9)

Guidance literature:

With iodine; magnesium; In diethyl ether; Inert atmosphere; Reflux;

DOI:10.1007/s11172-018-2235-z

Reference yield:

4-Bromodiphenyl ether (101-55-3) + ethyl acetoacetate (141-97-9) → 3-p-phenoxyphenyl-3-hydroxy-butyric acid ethyl ester (58727-44-9) + 4-phenoxyphenylmagnesium bromide (21473-02-9)

Guidance literature:

With magnesium;

upstream raw materials:

4-Bromodiphenyl ether

ethyl acetoacetate

Downstream raw materials:

2,2,2-trifluoro-1-(4-phenoxyphenyl)-ethanone

1-trimethylsilyl-4-phenoxybenzene

C₃₀H₃₆O₄Si₃

methyl(4-phenoxyphenyl)diphenylsilane

Refernces

• 1、 -. "Arylpiperidinopropanol and arylpiperazinopropanol derivatives and pharmaceuticals containing the same". . . Retrieved 2008/06/13.