C₃₂H₄₂N₂O₄Si

Base Information

• Chemical Name: C₃₂H₄₂N₂O₄Si
• CAS No.: 1269788-52-4
• Molecular Formula: C₃₂H₄₂N₂O₄Si
• Molecular Weight: 546.782
• Mol file: 1269788-52-4.mol

Synonyms:C₃₂H₄₂N₂O₄Si

Chemical Property of C₃₂H₄₂N₂O₄Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₄₂N₂O₄Si

There total 1 articles about C₃₂H₄₂N₂O₄Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 2-((3R,4S)-1-benzoyl-3-((tert-butyldimethylsilyloxy)methyl)piperidin-4-yl)acetate (1269788-51-3) + 6-methoxy-4-methylquinoline (41037-26-7) → C32H42N2O4Si (1269788-52-4)

Guidance literature:

6-methoxy-4-methylquinoline; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

ethyl 2-((3R,4S)-1-benzoyl-3-((tert-butyldimethylsilyloxy)methyl)piperidin-4-yl)acetate; In tetrahydrofuran; hexane; at -65 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.12.066

Reference yield:

C32H42N2O4Si (1269788-52-4) → quinindine (56-54-2,130-95-0,572-59-8,572-60-1,42151-59-7,47342-58-5,72402-50-7,72402-51-8,72402-52-9,72402-53-0,101143-86-6,101143-87-7,101143-88-8,146925-10-2)

Guidance literature:

Multi-step reaction with 12 steps

1.1: sodium tetrahydroborate / methanol / 2 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: pyridine / 1.5 h / 0 - 20 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

4.1: methanesulfonamide; hydroquinidein 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 72 h / 4 °C / Inert atmosphere

5.1: Trimethyl orthoacetate; pyridinium p-toluenesulfonate / dichloromethane / 5 h / 20 °C / Inert atmosphere

5.2: 3 h / 20 °C / Inert atmosphere

5.3: 2 h / 20 °C / Inert atmosphere

6.1: diisobutylaluminium hydride / hexane; toluene / 0.33 h / -78 °C / Inert atmosphere

7.1: N,N-dimethyl-formamide / 4 h / Reflux; Inert atmosphere

8.1: dmap; triethylamine / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

9.1: hydrogenchloride; methanol / 5 h / 20 °C / Inert atmosphere

10.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C / Inert atmosphere

10.2: -78 - 0 °C / Inert atmosphere

11.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

11.2: 0.5 h / 0 °C

12.1: methanol; potassium carbonate / 1.5 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; methanol; Trimethyl orthoacetate; dmap; sodium tetrahydroborate; oxalyl dichloride; methanesulfonamide; potassium tert-butylate; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene; tert-butyl alcohol; 10.1: Swern oxidation / 10.2: Swern oxidation / 11.1: Wittig reaction / 11.2: Wittig reaction;

DOI:10.1016/j.tetlet.2010.12.066

Reference yield:

C32H42N2O4Si (1269788-52-4) → C32H44N2O4Si

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h; Cooling with ice; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.12.066

upstream raw materials:

ethyl 2-((3R,4S)-1-benzoyl-3-((tert-butyldimethylsilyloxy)methyl)piperidin-4-yl)acetate

6-methoxy-4-methylquinoline

Downstream raw materials:

C₃₂H₄₂N₂O₃Si

C₃₂H₄₄N₂O₅Si

quinindine

quinidine acetate

Refernces