3-(1-TRITYL-1H-IMIDAZOL-4-YL)-PROPAN-1-YLAMINE

Base Information

• Chemical Name: 3-(1-TRITYL-1H-IMIDAZOL-4-YL)-PROPAN-1-YLAMINE
• CAS No.: 195053-89-5
• Molecular Formula: C25H25N3
• Molecular Weight: 367.494
• Hs Code.: 2933290090
• Mol file: 195053-89-5.mol

Synonyms:3-(1-Triphenylmethylimidazol-4-yl)propylamine;3-(1-trityl-1H-imidazol-4-yl)propan-1-amine;

Chemical Property of 3-(1-TRITYL-1H-IMIDAZOL-4-YL)-PROPAN-1-YLAMINE

Chemical Property:

• Vapor Pressure: 3.51E-11mmHg at 25°C
• Refractive Index: 1.607
• Boiling Point: 526.6 °C at 760 mmHg
• Flash Point: 272.3 °C
• PSA: 43.84000
• Density: 1.08 g/cm³
• LogP: 5.31490

Purity/Quality:

99% ^*data from raw suppliers

3-(1-Trityl-1H-imidazol-4-yl)propan-1-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(1-TRITYL-1H-IMIDAZOL-4-YL)-PROPAN-1-YLAMINE

There total 19 articles about 3-(1-TRITYL-1H-IMIDAZOL-4-YL)-PROPAN-1-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-[3-(1-trityl-1H-imidazol-4-yl)propyl]isoindoline-1,3-dione (195053-88-4) → 4-(3-aminopropyl)-1-(triphenylmethyl)-imidazole (195053-89-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Reflux; Inert atmosphere;

Reference yield: 67.0%

4-(3-chloropropyl)-1-(triphenylmethyl)-1H-imidazole hydrochloride → 4-(3-aminopropyl)-1-(triphenylmethyl)-imidazole (195053-89-5)

Guidance literature:

With tetrabutyl-ammonium chloride; ammonia; ammonium chloride; In ethanol; at 20 - 60 ℃; for 36h; under 15001.2 - 18751.5 Torr;

DOI:10.1016/S0968-0896(03)00120-2

Reference yield:

3-(1-trityl-1H-imidazol-4-yl)propan-1-ol (152030-49-4) → 4-(3-aminopropyl)-1-(triphenylmethyl)-imidazole (195053-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: DEAD, Ph₃P / tetrahydrofuran

2: 85 percent / H₂NNH₂*H₂O / ethanol / Heating

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol;

DOI:10.1021/ja973325x

upstream raw materials:

2-[3-(1-trityl-1H-imidazol-4-yl)propyl]isoindoline-1,3-dione

3-(1-Trityl-1H-imidazol-4-yl)-propionitrile

methylamine

N-trityl-4⁽⁵⁾-iodoimidazole

Downstream raw materials:

N-benzoyl-N'-(2-hydroxyethyl)-N-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}guanidine

N-benzoyl-N'-(3-hydroxypropyl)-N-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}guanidine

N-benzoyl-N'-[2-(4-phenyl-furazan-3-yloxy)-ethyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine

N-benzoyl-N'-[3-(4-phenyl-furazan-3-yloxy)-propyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine

Refernces

• 1、 -. "BIARYL MONOBACTAM COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF BACTERIAL INFECTIONS". Page/Page column 62. . Retrieved 2017/07/06.
• 2、 Igel, Patrick,Schneider, Erich,Schnell, David,Elz, Sigurd,Seifert, Roland,Buschauer, Armin. "Ng-acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the n g-substituent?". supporting information; experimental part. p. 2623 - 2627. Retrieved 2010/03/24.