O,O-diphenyl phosphorochloridothioate

Base Information

• Chemical Name: O,O-diphenyl phosphorochloridothioate
• CAS No.: 22077-44-7
• Molecular Formula: C₁₂H₁₀ClO₂PS
• Molecular Weight: 284.703
• Mol file: 22077-44-7.mol

Synonyms:O,O-diphenyl phosphorochloridothioate

Chemical Property of O,O-diphenyl phosphorochloridothioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O,O-diphenyl phosphorochloridothioate

There total 12 articles about O,O-diphenyl phosphorochloridothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

phenol (108-95-2,27073-41-2) → O,O-diphenyl phosphorochloridothioate (22077-44-7) + O-phenylphosphorodichloridothioate (18961-96-1)

Guidance literature:

With water; potassium carbonate; trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; at 20 - 40 ℃; for 1.6h;

Reference yield: 86.0%

Diphenyl phosphorochloridite (5382-00-3) → O,O-diphenyl phosphorochloridothioate (22077-44-7)

Guidance literature:

With sulfur; In toluene; for 16h; Reflux; Inert atmosphere;

Reference yield: 78.0%

phenol (108-95-2,27073-41-2) → O,O-diphenyl phosphorochloridothioate (22077-44-7)

Guidance literature:

phenol; With sodium hydride; In tetrahydrofuran; at -10 ℃;

With trichlorothiophosphine; In tetrahydrofuran; at -20 - 20 ℃; for 24h;

DOI:10.2174/1573406415666190716115524

upstream raw materials:

Bis disulfide

O,O-diphenyl phosphorodithioic acid

phenyl phosphorodichloridite

Diphenyl phosphorochloridite

Downstream raw materials:

(4-methoxy-phenyl)-amidothiophosphoric acid O,O'-diphenyl ester

1,3-Bis-diphenoxythiophosphinylaminopropan

2-diphenoxythiophosphoryliminothiazolidine

{2-[(E)-Diphenoxy-thiophosphorylimino]-thiazolidin-3-yl}-phosphonothioic acid O,O-diphenyl ester

Refernces

• 1、 Loranger, Matthew W.,Beaton, Stephen A.,Lines, Katie L.,Jakeman, David L.. "Thiophosphate and thiophosphonate analogues of glucose-1-phosphate: Synthesis and enzymatic activity with a thymidylyltransferase". . p. 43 - 50. Retrieved 2013.
• 2、 -. "Curcumin phosphate compound, preparation method and uses thereof". Paragraph 0129; 0130; 0131. . Retrieved 2016/10/08.