Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI)

Base Information

• Chemical Name: Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI)
• CAS No.: 191478-99-6
• Molecular Formula: C8H7 F2 N O2
• Molecular Weight: 187.146
• Hs Code.: 2916399090
• Mol file: 191478-99-6.mol

Synonyms:Methyl4-amino-2,6-difluorobenzoate

Chemical Property of Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI)

Chemical Property:

• Boiling Point: 306℃
• PKA: 0.44±0.10(Predicted)
• Flash Point: 139℃
• PSA: 52.32000
• Density: 1.355
• LogP: 1.91480
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

Methyl4-amino-2,6-difluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI)

There total 6 articles about Benzoic acid, 4-amino-2,6-difluoro-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-((tert-butyloxycarbonyl)amino)-2,6-difluorobenzoate (129589-63-5) → methyl 4-amino-2,6-difluorobenzoate (191478-99-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

4-(benzhydrylidene-amino)-2,6-difluoro-benzoic acid methyl ester (1329166-92-8) → methyl 4-amino-2,6-difluorobenzoate (191478-99-6)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

methanol (67-56-1) + 2,4,6-trifluorobenzoic acid (28314-80-9) → methyl 4-amino-2,6-difluorobenzoate (191478-99-6)

Guidance literature:

methanol; 2,4,6-trifluorobenzoic acid; With thionyl chloride; In pyridine;

With sodium azide; In acetonitrile;

With hydrogen; palladium over charcoal;

upstream raw materials:

methanol

2,4,6-trifluorobenzoic acid

4-bromo-2,6-difluorobenzoic acid

4-bromo-2,6-difluorobenzoic acid methyl ester

Refernces

• 1、 -. "SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF". . . Retrieved 2015/02/25.
• 2、 -. "Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thichroman and 1,2,3,4-tetrahydroquinolinecarboxlic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity". Page column 21,29. . Retrieved 2010/11/29.