Magnesium bromide 5-fluoro-2-methoxybenzen-1-ide (1/1/1)

Base Information

• Chemical Name: Magnesium bromide 5-fluoro-2-methoxybenzen-1-ide (1/1/1)
• CAS No.: 188132-02-7
• Molecular Formula: C7H6BrFMgO
• Molecular Weight: 229.331
• Hs Code.: 29310099
• DSSTox Substance ID: DTXSID50381174
• Mol file: 188132-02-7.mol

Synonyms:Magnesium bromide 5-fluoro-2-methoxybenzen-1-ide (1/1/1);magnesium;1-fluoro-4-methoxybenzene-5-ide;bromide;DTXSID50381174

Chemical Property of Magnesium bromide 5-fluoro-2-methoxybenzen-1-ide (1/1/1)

Chemical Property:

• Vapor Pressure: 3.51mmHg at 25°C
• Boiling Point: 65 °C
• Flash Point: 1 °F
• PSA: 9.23000
• Density: 0.948 g/mL at 25 °C
• LogP: 2.48010
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 227.94365
• Heavy Atom Count: 11
• Complexity: 189

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Fluoro-2-methoxyphenylmagnesiumbromide,0.5MinTHF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F;C
• Hazard Codes: F,C,Xn
• Statements: 11-14/15-19-34-40-36/37
• Safety Statements: 16-26-33-36/37/39-43-45-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=[C-]C=C(C=C1)F.[Mg+2].[Br-]

Technology Process of Magnesium bromide 5-fluoro-2-methoxybenzen-1-ide (1/1/1)

There total 1 articles about Magnesium bromide 5-fluoro-2-methoxybenzen-1-ide (1/1/1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-4-fluoro-1-methoxybenzene (452-08-4) → (5-fluoro-2-methoxyphenyl)magnesium bromide (188132-02-7)

Guidance literature:

With isopropylmagnesium chloride; In tetrahydrofuran; at 30 ℃; for 16.5h;

Reference yield: 100.0%

3-bromo-2-fluorobenzaldehyde (149947-15-9) + (5-fluoro-2-methoxyphenyl)magnesium bromide (188132-02-7) → (3-bromo-2-fluorophenyl)(5-fluoro-2-methoxyphenyl)methanol (1428881-51-9)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃;

Reference yield: 96.0%

6-chloro-2-methyl-4H-benzo[d][1,3]oxazin-4-one (7033-50-3) + (5-fluoro-2-methoxyphenyl)magnesium bromide (188132-02-7) → (2-amino-5-chloro-phenyl)-(5-fluoro-2-methoxy-phenyl)-methanone (406684-56-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0968-0896(01)00290-5

upstream raw materials:

2-bromo-4-fluoro-1-methoxybenzene

Downstream raw materials:

(2-amino-5-chloro-phenyl)-(5-fluoro-2-methoxy-phenyl)-methanone

1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-one

2-[2-(5-fluoro-2-methoxyphenyl)-2-methylpropyl]-2-(trifluoromethyl)oxirane

1-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentyl]-1H-quinolin-4-one

Refernces