Technology Process of (tert-butyl)((4R,6R)-6-(4-methoxybenzyloxy)oct-7-en-4-yloxy)dimethylsilane
There total 10 articles about (tert-butyl)((4R,6R)-6-(4-methoxybenzyloxy)oct-7-en-4-yloxy)dimethylsilane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetra-(n-butyl)ammonium iodide; sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
DOI:10.1016/j.tetasy.2007.07.022
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 94 percent / imidazole / CH2Cl2 / 2.5 h / 20 °C
2: osmium tetroxide; 2,6-lutidine; NaIO4 / dioxane; H2O; toluene / 3 h / 25 °C
3: 4.42 g / benzene / 6 h / Heating
4: 95 percent / osmium tetroxide; potassium ferricyanide; K2CO3 / (DHQD)2PHAL; methanesulfonamide / 2-methyl-propan-2-ol; H2O; toluene / 24 h / 0 °C
5: 91 percent / p-TSA / CH2Cl2 / 1.5 h
6: 88 percent / DIBAL-H / CH2Cl2; toluene / 2 h / 0 - 20 °C
7: triethylamine / CH2Cl2 / 2 h / 20 °C
8: 1.58 g / NaI / butan-2-one / 6 h / Heating
9: 92 percent / zinc / ethanol / 3 h / Heating
10: 90 percent / sodium hydride; tetra-n-butylammonium iodide / tetrahydrofuran / 1 h / 0 °C
With
1H-imidazole; 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; sodium iodide; potassium hexacyanoferrate(III); zinc;
methanesulfonamide; 1,4-bis(9-O-dihydroquinidine)phthalazine;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene; butanone; tert-butyl alcohol; benzene;
4: Sharpless dihydroxylation;
DOI:10.1016/j.tetasy.2007.07.022
- Guidance literature:
-
Multi-step reaction with 9 steps
1: osmium tetroxide; 2,6-lutidine; NaIO4 / dioxane; H2O; toluene / 3 h / 25 °C
2: 4.42 g / benzene / 6 h / Heating
3: 95 percent / osmium tetroxide; potassium ferricyanide; K2CO3 / (DHQD)2PHAL; methanesulfonamide / 2-methyl-propan-2-ol; H2O; toluene / 24 h / 0 °C
4: 91 percent / p-TSA / CH2Cl2 / 1.5 h
5: 88 percent / DIBAL-H / CH2Cl2; toluene / 2 h / 0 - 20 °C
6: triethylamine / CH2Cl2 / 2 h / 20 °C
7: 1.58 g / NaI / butan-2-one / 6 h / Heating
8: 92 percent / zinc / ethanol / 3 h / Heating
9: 90 percent / sodium hydride; tetra-n-butylammonium iodide / tetrahydrofuran / 1 h / 0 °C
With
2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; sodium iodide; potassium hexacyanoferrate(III); zinc;
methanesulfonamide; 1,4-bis(9-O-dihydroquinidine)phthalazine;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene; butanone; tert-butyl alcohol; benzene;
3: Sharpless dihydroxylation;
DOI:10.1016/j.tetasy.2007.07.022