Technology Process of 1-(2-(3-chloro-5-methylphenyl)-4-methyl-6-(3-phenoxyphenyl)pyrimidin-5-yl)ethanone
There total 5 articles about 1-(2-(3-chloro-5-methylphenyl)-4-methyl-6-(3-phenoxyphenyl)pyrimidin-5-yl)ethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C19H15ClN2O2; (3-chloro-5-methylphenyl)boronic acid;
In
1,4-dioxane;
at 20 ℃;
for 0.0833333h;
Inert atmosphere;
With
palladium diacetate; sodium carbonate; triphenylphosphine;
In
1,4-dioxane;
at 20 - 110 ℃;
for 3.5h;
Inert atmosphere;
DOI:10.1016/j.tetlet.2014.01.042
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N,N-dimethyl-aniline; trichlorophosphate / 12 h / Reflux
2.1: 1,4-dioxane / 0.08 h / 20 °C / Inert atmosphere
2.2: 3.5 h / 20 - 110 °C / Inert atmosphere
With
N,N-dimethyl-aniline; trichlorophosphate;
In
1,4-dioxane;
2.1: |Suzuki-Miyaura Coupling / 2.2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.tetlet.2014.01.042
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / water; ethanol / 3 h / Reflux
2.1: nitric acid / water / 0 - 20 °C
3.1: N,N-dimethyl-aniline; trichlorophosphate / 12 h / Reflux
4.1: 1,4-dioxane / 0.08 h / 20 °C / Inert atmosphere
4.2: 3.5 h / 20 - 110 °C / Inert atmosphere
With
hydrogenchloride; nitric acid; N,N-dimethyl-aniline; trichlorophosphate;
In
1,4-dioxane; ethanol; water;
1.1: |Biginelli Pyrimidone Synthesis / 4.1: |Suzuki-Miyaura Coupling / 4.2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.tetlet.2014.01.042