Technology Process of Pyrrolo[1,2-a][1,4]diazocine-1,6-dione, octahydro- (9CI)
There total 4 articles about Pyrrolo[1,2-a][1,4]diazocine-1,6-dione, octahydro- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dicyclohexyl-carbodiimide;
dmap;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 96h;
DOI:10.1007/BF02219346
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 88 percent / ethyl acetate; dimethylformamide / 2 h / -10 - 20 °C
2: 92 percent / NaOH; HCl / methanol / 2 h
3: 94 percent / H2 / 10 percent Pd/C / methanol / 2 h
4: 31 percent / dicyclohexylcarbodiimide / 4-(dimethylamino)pyridine / dimethylformamide / 96 h / 20 °C
With
hydrogenchloride; sodium hydroxide; hydrogen; dicyclohexyl-carbodiimide;
dmap; 10% palladium on active carbon;
In
methanol; ethyl acetate; N,N-dimethyl-formamide;
1: Addition / 2: Hydrogenation / 3: Hydrogenation / 4: Cyclization;
DOI:10.1007/BF02219346
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 94 percent / H2 / 10 percent Pd/C / methanol / 2 h
2: 31 percent / dicyclohexylcarbodiimide / 4-(dimethylamino)pyridine / dimethylformamide / 96 h / 20 °C
With
hydrogen; dicyclohexyl-carbodiimide;
dmap; 10% palladium on active carbon;
In
methanol; N,N-dimethyl-formamide;
1: Hydrogenation / 2: Cyclization;
DOI:10.1007/BF02219346
