2-Naphthalenecarboxylic acid, 5,6-dihydroxy- (9CI)

Base Information

• Chemical Name: 2-Naphthalenecarboxylic acid, 5,6-dihydroxy- (9CI)
• CAS No.: 182205-62-5
• Molecular Formula: C11H8 O4
• Molecular Weight: 204.17882
• Mol file: 182205-62-5.mol

Synonyms:5,6-Dihydroxy-2-naphthoicacid; NSC 689403

Chemical Property of 2-Naphthalenecarboxylic acid, 5,6-dihydroxy- (9CI)

Chemical Property:

• PSA: 77.76000
• LogP: 1.94920

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Naphthalenecarboxylic acid, 5,6-dihydroxy- (9CI)

There total 1 articles about 2-Naphthalenecarboxylic acid, 5,6-dihydroxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5,6-dimethoxy-2-naphthalenecarboxylic acid (126674-76-8) → 5,6-dihydroxy-2-naphthoic acid (182205-62-5)

Guidance literature:

With pyridine hydrochloride; at 180 - 200 ℃; for 1.5h;

DOI:10.1021/jm960449w

Reference yield: 77.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + 5,6-dihydroxy-2-naphthoic acid (182205-62-5) → 5,6-Dihydroxy-naphthalene-2-carboxylic acid pentafluorophenyl ester (188662-04-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In 1,4-dioxane; Ambient temperature;

DOI:10.1021/jm960449w

Reference yield:

2-phenylethanol (60-12-8) + 5,6-dihydroxy-2-naphthoic acid (182205-62-5) → 5,6-Dihydroxy-2-naphthoic acid β-phenylethyl ester

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 48h; Yield given; Heating;

DOI:10.1021/jm00021a006

upstream raw materials:

5,6-dimethoxy-2-naphthalenecarboxylic acid

Downstream raw materials:

5,6-Dihydroxy-naphthalene-2-carboxylic acid pentafluorophenyl ester

Refernces

• 1、 Burke Jr.,Fesen,Mazumder,Wang,Carothers,Grunberger,Driscoll,Kohn,Pommier. "Hydroxylated aromatic inhibitors of HIV-1 integrase". . p. 4171 - 4178. Retrieved 2007/10/03.