N-(4-fluorophenyl)-nitramine

Base Information

• Chemical Name: N-(4-fluorophenyl)-nitramine
• CAS No.: 61161-10-2
• Molecular Formula: C₆H₅FN₂O₂
• Molecular Weight: 156.116
• Mol file: 61161-10-2.mol

Synonyms:N-(4-fluorophenyl)-nitramine

Chemical Property of N-(4-fluorophenyl)-nitramine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-fluorophenyl)-nitramine

There total 1 articles about N-(4-fluorophenyl)-nitramine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-fluoroaniline (371-40-4) → N-(4-fluorophenyl)-nitramine (61161-10-2)

Guidance literature:

4-fluoroaniline; With methyl magnesium iodide; In toluene; for 3h; Heating;

With butyl nitrate; In toluene; at 20 ℃; for 3h;

DOI:10.1002/poc.461

Reference yield:

N-(4-fluorophenyl)-nitramine (61161-10-2) → 4-fluorophenylhydrazine (371-14-2)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; In water; for 4h; Cooling with ice;

DOI:10.1016/j.tet.2013.11.084

Reference yield:

N-(4-fluorophenyl)-nitramine (61161-10-2) → ethyl 2-[2-(4-fluorophenyl)hydrazinylidene]propanoate (351-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; tin(ll) chloride / water / 4 h / Cooling with ice

2: ethanol / 5 h / Inert atmosphere; Reflux

With hydrogenchloride; tin(ll) chloride; In ethanol; water;

DOI:10.1016/j.tet.2013.11.084

upstream raw materials:

4-fluoroaniline

Downstream raw materials:

4-fluorophenylhydrazine

ethyl 2-[2-(4-fluorophenyl)hydrazinylidene]propanoate

ethyl 5-fluoro-1H-indole-2-carboxylate

Refernces

• 1、 Yang, Yan-Fang,Li, Lian-Hua,He, Yu-Tao,Luo, Jian-Yi,Liang, Yong-Min. "Gold(I)-catalyzed rearrangement of alkynylaziridine indoles for the synthesis of spiro-tetrahydro-β-carbolines". supporting information. p. 702 - 707. Retrieved 2014/02/14.