(R)-phenylglycine nitrile

Base Information

• Chemical Name: (R)-phenylglycine nitrile
• CAS No.: 45789-64-8
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.165
• Mol file: 45789-64-8.mol

Synonyms:(R)-phenylglycine nitrile

Chemical Property of (R)-phenylglycine nitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-phenylglycine nitrile

There total 5 articles about (R)-phenylglycine nitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-amino-2-phenylacetonitrile (16750-42-8,41804-94-8) → (R)-phenylglycine nitrile (45789-64-8)

Guidance literature:

With recombinant sphingomonas wittichii RW₁ nitrilase; In methanol; water; at 25 ℃; for 48h; Solvent; pH-value; Temperature; enantioselective reaction; Enzymatic reaction;

DOI:10.1016/j.tetlet.2014.01.044

Reference yield:

2-amino-2-phenylacetonitrile (16750-42-8,41804-94-8) → L-phenylglycine amide (6485-52-5) + (R)-phenylglycine amide (700-63-0,6485-52-5,6485-67-2,58429-87-1) + (R)-phenylglycine (875-74-1) + (R)-phenylglycine nitrile (45789-64-8)

Guidance literature:

With phosphate buffer; Pantoea sp. 17.3.1 permeabilized cells; Triton X-100; at 4 ℃; for 0.333333h; pH=7.4;

DOI:10.1016/S0957-4166(02)00751-6

Reference yield:

2-amino-2-phenylacetonitrile (16750-42-8,41804-94-8) → (S)-2-phenylglycine (2935-35-5) + (S)-α-phenylglycinenitrile (48108-77-6) + (R)-phenylglycine nitrile (45789-64-8)

Guidance literature:

With water; In aq. phosphate buffer; at 25 ℃; for 96h; pH=7; pH-value; Microbiological reaction; Resolution of racemate;

DOI:10.1002/open.202000088

upstream raw materials:

2-amino-2-phenylacetonitrile

Downstream raw materials:

(R)-phenylglycine amide

Refernces

• 1、 Coady, Tracey M.,Coffey, Lee,Kinsella, Michael,Lennon, Claire M.,Mareya, Tatenda M.,O'Reilly, Catherine. "Process Optimisation Studies and Aminonitrile Substrate Evaluation of Rhodococcus erythropolis SET1, A Nitrile Hydrolyzing Bacterium". . p. 512 - 520. Retrieved 2020/10/02.
• 2、 Hensel, Martina,Lutz-Wahl, Sabine,Fischer, Lutz. "Stereoselective hydration of (RS)-phenylglycine nitrile by new whole cell biocatalysts". . p. 2629 - 2633. Retrieved 2007/10/03.