(9-Benzyl-9H-purin-6-yl)-methyl-dithiocarbamic acid ethyl ester

Base Information

• Chemical Name: (9-Benzyl-9H-purin-6-yl)-methyl-dithiocarbamic acid ethyl ester
• CAS No.: 213190-51-3
• Molecular Formula: C₁₆H₁₇N₅S₂
• Molecular Weight: 343.476
• Mol file: 213190-51-3.mol

Synonyms:(9-Benzyl-9H-purin-6-yl)-methyl-dithiocarbamic acid ethyl ester

Chemical Property of (9-Benzyl-9H-purin-6-yl)-methyl-dithiocarbamic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (9-Benzyl-9H-purin-6-yl)-methyl-dithiocarbamic acid ethyl ester

There total 3 articles about (9-Benzyl-9H-purin-6-yl)-methyl-dithiocarbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

ethyl chlorodithioformate (35447-70-2) + methyl-(9-benzyl-9H-purin-6-yl)amine (81060-73-3) → (9-Benzyl-9H-purin-6-yl)-methyl-dithiocarbamic acid ethyl ester (213190-51-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 2h;

DOI:10.1246/bcsj.71.1973

Reference yield:

9-benzyl-6-chloro-9H-purine (1928-76-3) → (9-Benzyl-9H-purin-6-yl)-methyl-dithiocarbamic acid ethyl ester (213190-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / triethylamine / CH₂Cl₂ / 12 h / Ambient temperature

2: 37 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / 0 - 20 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1246/bcsj.71.1973

Reference yield:

benzyl bromide (100-39-0) → (9-Benzyl-9H-purin-6-yl)-methyl-dithiocarbamic acid ethyl ester (213190-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / NaH / dimethylformamide / 3 h / 0 - 20 °C

2: 93 percent / triethylamine / CH₂Cl₂ / 12 h / Ambient temperature

3: 37 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / 0 - 20 °C

With n-butyllithium; sodium hydride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.71.1973

upstream raw materials:

ethyl chlorodithioformate

methyl-(9-benzyl-9H-purin-6-yl)amine

9-benzyl-6-chloro-9H-purine

benzyl bromide

Refernces