Pyridine, 2-fluoro-4-methoxy- (9CI)

Base Information

• Chemical Name: Pyridine, 2-fluoro-4-methoxy- (9CI)
• CAS No.: 175965-83-0
• Molecular Formula: C6H6 F N O
• Molecular Weight: 127.1163432
• Hs Code.: 2933399990
• Mol file: 175965-83-0.mol

Synonyms:2-Fluoro-4-methoxypyridine

Chemical Property of Pyridine, 2-fluoro-4-methoxy- (9CI)

Chemical Property:

• Vapor Pressure: 2.33mmHg at 25°C
• Refractive Index: 1.471
• Boiling Point: 166.6ºC at 760 mmHg
• Flash Point: 54.6ºC
• PSA: 22.12000
• Density: 1.146
• LogP: 1.22930
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-4-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 2-fluoro-4-methoxy- (9CI)

There total 3 articles about Pyridine, 2-fluoro-4-methoxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-methoxypyridin-2(1H)-one (52545-13-8) + Cl(1-)*C27H36ClN2(1+)*Cs(1+)*F(1-) → 2-fluoro-4-methoxypyridine (175965-83-0)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; at 23 - 140 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol5035518

Reference yield:

4-methoxypyridine (620-08-6,1232006-56-2) → 2-fluoro-4-methoxypyridine (175965-83-0)

Guidance literature:

With silver(II) fluoride; In acetonitrile; at 20 ℃; for 1h; Mechanism;

DOI:10.1126/science.1243759

Reference yield:

→ 2-fluoro-4-methoxypyridine (175965-83-0)

Guidance literature:

With silver(II) fluoride; In acetonitrile; at 25 ℃; for 1h; Inert atmosphere; Glovebox;

upstream raw materials:

4-methoxypyridine

4-methoxypyridin-2(1H)-one

Downstream raw materials:

2-fluoro-6-methoxypyridinecarboxyaldehyde

Refernces

• 1、 Fujimoto, Teppei,Ritter, Tobias. "PhenoFluorMix: Practical chemoselective deoxyfluorination of phenols". supporting information. p. 544 - 547. Retrieved 2015/03/05.