Propanamide, N-methyl-N-3-piperidinyl-

Base Information

• Chemical Name: Propanamide, N-methyl-N-3-piperidinyl-
• CAS No.: 172477-97-3
• Molecular Formula: C₉H₁₈N₂O
• Molecular Weight: 170.255
• Mol file: 172477-97-3.mol

Synonyms:Propanamide, N-methyl-N-3-piperidinyl-

Chemical Property of Propanamide, N-methyl-N-3-piperidinyl-

Chemical Property:

• Boiling Point: 285.2±29.0 °C(Predicted)
• PKA: 9.49±0.10(Predicted)
• PSA: 32.34000
• Density: 0.99±0.1 g/cm3(Predicted)
• LogP: 0.93560

Purity/Quality:

N-METHYL-N-(PIPERIDIN-3-YL)PROPANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanamide, N-methyl-N-3-piperidinyl-

There total 3 articles about Propanamide, N-methyl-N-3-piperidinyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-benzyl-3-methylpropionylamino-piperidine (172477-95-1) → 3-methylpropionylamino-piperidine (172477-97-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;

DOI:10.1016/0040-4020(95)00716-L

Reference yield:

1-benzyl-3-piperidone (40114-49-6) → 3-methylpropionylamino-piperidine (172477-97-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / NaBH₄ / methanol; H₂O / 1 h / Ambient temperature

2: 90 percent / 1 h / 100 °C

3: 85 percent / H₂ / 10percent Pd/C / ethanol / Ambient temperature

With sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In methanol; ethanol; water;

DOI:10.1016/0040-4020(95)00716-L

Reference yield:

1-benzyl-N-methylpiperidin-3-amine (60717-45-5) → 3-methylpropionylamino-piperidine (172477-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / 1 h / 100 °C

2: 85 percent / H₂ / 10percent Pd/C / ethanol / Ambient temperature

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/0040-4020(95)00716-L

upstream raw materials:

1-benzyl-3-methylpropionylamino-piperidine

1-benzyl-3-piperidone

1-benzyl-N-methylpiperidin-3-amine

Refernces