2-(2,2,2-trifluoroethylsulfinyl)-4-(4-oxo-quinazolin-3-yl)-5-fluoro-toluene

Base Information

• Chemical Name: 2-(2,2,2-trifluoroethylsulfinyl)-4-(4-oxo-quinazolin-3-yl)-5-fluoro-toluene
• CAS No.: 1242552-48-2
• Molecular Formula: C₁₇H₁₂F₄N₂O₂S
• Molecular Weight: 384.354
• Mol file: 1242552-48-2.mol

Synonyms:2-(2,2,2-trifluoroethylsulfinyl)-4-(4-oxo-quinazolin-3-yl)-5-fluoro-toluene

Chemical Property of 2-(2,2,2-trifluoroethylsulfinyl)-4-(4-oxo-quinazolin-3-yl)-5-fluoro-toluene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,2,2-trifluoroethylsulfinyl)-4-(4-oxo-quinazolin-3-yl)-5-fluoro-toluene

There total 9 articles about 2-(2,2,2-trifluoroethylsulfinyl)-4-(4-oxo-quinazolin-3-yl)-5-fluoro-toluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.9%

2-(2,2,2-trifluoroethylsulfanyl)-4-(4-oxo-quinazolin-3-yl)-5-fluoro-toluene (1242552-44-8) → 2-(2,2,2-trifluoroethylsulfinyl)-4-(4-oxo-quinazolin-3-yl)-5-fluoro-toluene (1242552-48-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; for 1h; Ice-cooling;

Reference yield:

2-fluoro-4-methylaniline (452-80-2) → 2-(2,2,2-trifluoroethylsulfinyl)-4-(4-oxo-quinazolin-3-yl)-5-fluoro-toluene (1242552-48-2)

Guidance literature:

Multi-step reaction with 9 steps

1: triethylamine / dichloromethane / 2 h / 0 °C

2: chlorosulfonic acid / 3 h / 70 °C

3: acetic acid; phosphorus; iodine / 3 h / Reflux

4: potassium hydroxide / water / 5 h / Reflux

5: potassium hydroxide; rongalite / N,N-dimethyl-formamide / 2 h / 20 °C

6: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

7: hydrogen / ethanol / 20 °C / 760.05 Torr

8: sulfuric acid / 5 h / 140 °C

9: 3-chloro-benzenecarboperoxoic acid / chloroform / 1 h / Cooling with ice

With chlorosulfonic acid; sulfuric acid; phosphorus; hydrogen; iodine; rongalite; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium hydroxide; In ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

N-(2-fluoro-4-methylphenyl)acetamide (326-67-0) → 2-(2,2,2-trifluoroethylsulfinyl)-4-(4-oxo-quinazolin-3-yl)-5-fluoro-toluene (1242552-48-2)

Guidance literature:

Multi-step reaction with 8 steps

1: chlorosulfonic acid / 3 h / 70 °C

2: acetic acid; phosphorus; iodine / 3 h / Reflux

3: potassium hydroxide / water / 5 h / Reflux

4: potassium hydroxide; rongalite / N,N-dimethyl-formamide / 2 h / 20 °C

5: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

6: hydrogen / ethanol / 20 °C / 760.05 Torr

7: sulfuric acid / 5 h / 140 °C

8: 3-chloro-benzenecarboperoxoic acid / chloroform / 1 h / Cooling with ice

With chlorosulfonic acid; sulfuric acid; phosphorus; hydrogen; iodine; rongalite; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium hydroxide; In ethanol; chloroform; water; N,N-dimethyl-formamide;

upstream raw materials:

2-(2,2,2-trifluoroethylsulfanyl)-4-(4-oxo-quinazolin-3-yl)-5-fluoro-toluene

N-(2-fluoro-5-mercapto-4-methylphenyl)acetamide

5-amino-4-fluoro-2-methylbenzene-1-thiol

N-(2-nitro-benzoyl)-3-(2,2,2-trifluoroethylsulfanyl)-4-methyl-6-fluoro-aniline

Refernces

• 1、 -. "USE OF PESTICIDAL ACTIVE 3-ARYLQUINAZOLIN-4-ONE DERIVATIVES IN SOIL APPLICATION METHODS". Page/Page column 51. . Retrieved 2013/03/28.
• 2、 -. "3-ARYLQUINAZOLIN-4-ONE COMPOUNDS FOR COMBATING INVERTEBRATE PESTS". Page/Page column 72. . Retrieved 2010/09/18.