IP-FOXAP

Base Information

• Chemical Name: IP-FOXAP
• CAS No.: 163169-10-6
• Molecular Formula: C₂₈H₂₈FeNOP
• Molecular Weight: 481.357
• Mol file: 163169-10-6.mol

Synonyms:Ferrocene,1-[4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-2-(diphenylphosphino)-,[R-(R*,S*)]-;(2R)-1-[(4S)-4,5-Dihydro-4-(1-methylethyl)-2-oxazolyl]-2-(diphenylphosphino)ferrocene

Chemical Property of IP-FOXAP

Chemical Property:

• Melting Point: approximate 160℃
• PSA: 22.82000
• LogP: 5.85780
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2R)-1-[(4S)-4,5-Dihydro-4-(1-methylethyl)-2-oxazolyl]-2-(diphenylphosphino)ferrocene 97%(99%ee) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of IP-FOXAP

There total 1 articles about IP-FOXAP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3,5-dihydrodinaphtho[2,1-c:1',2'-e]selenepin 4-oxide (297163-59-8) + rac-[2-(4-isopropyl-2-oxazoline-2-yl)ferrocenyl]diphenylphosphine (1065474-88-5,541540-70-9,163169-29-7,163169-10-6,544697-49-6) → [2-(4-isopropyl-2-oxazoline-2-yl)ferrocenyl]diphenylphosphine (541540-70-9,1065474-88-5,544697-49-6,163169-10-6,163169-29-7) + [2-(4-isopropyl-2-oxazoline-2-yl)ferrocenyl]diphenylphosphine oxide*H2O

Guidance literature:

With phenol; In tetrachloromethane; under N2; soln. of selenoxide and phenol in CCl4 stirred at room temp. for 15 min, added phosphine in CCl4, stirred at room temp. for 24 h; chromy. (SiO2), enantiomeric excess of phosphine and phosphine oxide 18%and 21% respectively; elem. anal. for phosphine oxide;

DOI:10.1246/bcsj.76.381

Reference yield:

bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate (35138-22-8) + rac-[2-(4-isopropyl-2-oxazoline-2-yl)ferrocenyl]diphenylphosphine (1065474-88-5,541540-70-9,163169-29-7,163169-10-6,544697-49-6) → BF4(1-)*Rh(1+)*C8H12*C28H28FeNOP

Guidance literature:

In toluene; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

(R)-3,5-dihydrodinaphtho[2,1-c:1',2'-e]selenepin 4-oxide (297163-59-8) + rac-[2-(4-isopropyl-2-oxazoline-2-yl)ferrocenyl]diphenylphosphine (1065474-88-5,541540-70-9,163169-29-7,163169-10-6,544697-49-6) → [2-(4-isopropyl-2-oxazoline-2-yl)ferrocenyl]diphenylphosphine (541540-70-9,1065474-88-5,544697-49-6,163169-10-6,163169-29-7) + [2-(4-isopropyl-2-oxazoline-2-yl)ferrocenyl]diphenylphosphine oxide*H2O

Guidance literature:

With phenol; In tetrachloromethane; under N2; soln. of selenoxide and phenol in CCl4 stirred at room temp. for 15 min, added phosphine in CCl4, stirred at room temp. for 24 h; chromy. (SiO2), enantiomeric excess of phosphine and phosphine oxide 18%and 21% respectively; elem. anal. for phosphine oxide;

DOI:10.1246/bcsj.76.381

upstream raw materials:

(R)-3,5-dihydrodinaphtho[2,1-c:1',2'-e]selenepin 4-oxide

rac-[2-(4-isopropyl-2-oxazoline-2-yl)ferrocenyl]diphenylphosphine

Downstream raw materials:

[2-(4-isopropyl-2-oxazoline-2-yl)ferrocenyl]diphenylphosphine

Refernces