Benzyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate

Base Information

• Chemical Name: Benzyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate
• CAS No.: 161609-80-9
• Molecular Formula: C14H19 N3 O3
• Molecular Weight: 277.323
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90593597
• Wikidata: Q82488100
• Mol file: 161609-80-9.mol

Synonyms:161609-80-9;benzyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate;4-HYDRAZINOCARBONYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;1-N-Cbz-piperidine-4-carboxylic acid hydrazide;1,4-Piperidinedicarboxylic acid, 1-(phenylmethyl) ester, 4-hydrazide;DHNZPTXPFMSBML-UHFFFAOYSA-N;SCHEMBL2712060;DTXSID90593597;MFCD06795951;AKOS015909029;SB34046;AS-11233;DB-114279;CS-0447610;A918887;n-benzyloxycarbonyl-4-(hydrazinocarbonyl)piperidine;benzyl 4(hydrazinocarbonyl)piperidine-1-carboxylate;benzyl4-(hydrazinecarbonyl)piperidine-1-carboxylate

Chemical Property of Benzyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate

Chemical Property:

• Boiling Point: 498.3±44.0 °C(Predicted)
• PKA: 13.01±0.20(Predicted)
• PSA: 84.66000
• Density: 1.243±0.06 g/cm3(Predicted)
• LogP: 2.05420
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 277.14264148
• Heavy Atom Count: 20
• Complexity: 335

Purity/Quality:

99% ^*data from raw suppliers

4-Hydrazinocarbonyl-piperidine-1-carboxylicacidbenzylester 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1C(=O)NN)C(=O)OCC2=CC=CC=C2
• Uses: N-Cbz-4-piperidinecarboxylic Acid Hydrazide can be used as muscarinic M1 receptor agonists to treat muscarinic M1?/M4 receptor mediated diseases.

Technology Process of Benzyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate

There total 7 articles about Benzyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-benzyl 4-ethyl piperidine-1,4-dicarboxylate (160809-38-1) → benzyl 4-(hydrazinylcarbonyl)piperidine-1-carboxylate (161609-80-9)

Guidance literature:

With hydrazine hydrate; In ethanol; at 90 ℃;

Reference yield: 71.0%

piperidine-1,4-dicarboxylic acid 1-benzyl ester 4-methyl ester (138163-07-2) → benzyl 4-(hydrazinylcarbonyl)piperidine-1-carboxylate (161609-80-9)

Guidance literature:

With hydrazine hydrate; In methanol; for 48h;

DOI:10.1016/j.tetlet.2019.04.010

Reference yield:

→ benzyl 4-(hydrazinylcarbonyl)piperidine-1-carboxylate (161609-80-9) + carbonodihydrazide (497-18-7)

Guidance literature:

upstream raw materials:

1-benzyl 4-ethyl piperidine-1,4-dicarboxylate

1-benzyloxycarbonylpiperidine-4-carboxylic acid

4-carbethoxypiperidine

benzyl chloroformate

Downstream raw materials:

C₂₁H₂₃ClN₄O₃S

C₂₈H₃₅N₇O₄

Refernces

• 1、 -. "BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 RECEPTOR AGONISTS.". Page/Page column 68. . Retrieved 2015/09/22.
• 2、 -. "AZOLE DERIVATIVES AS WTN PATHWAY INHIBITORS". Page/Page column 117; 119. . Retrieved 2010/12/29.