Technology Process of N-(tert-butoxycarbonyl)methyl-D-diphenylalanyl-L-prolyl[(5-hydroxyamidino-2-thienyl)methyl]amide
There total 8 articles about N-(tert-butoxycarbonyl)methyl-D-diphenylalanyl-L-prolyl[(5-hydroxyamidino-2-thienyl)methyl]amide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroxylamine hydrochloride; sodium carbonate;
In
ethanol;
for 1h;
Heating;
DOI:10.1021/jm030025j
- Guidance literature:
-
Multi-step reaction with 8 steps
1: dimethylformamide / Heating
2: 86 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 6 h / Heating
3: NaH / tetrahydrofuran / 3 h
4: 2.4 g / HCl(g) / ethyl acetate / 0 - 20 °C
5: 86 percent / EDC; HOBT; Et3N / dimethylformamide / 20 °C
6: 100 percent / HCl / ethyl acetate / 3 h / 20 °C
7: 72 percent / iPr2NEt / acetonitrile / 48 h / 20 °C
8: 96 percent / aq. NH2OH*HCl; Na2CO3 / ethanol / 1 h / Heating
With
hydrogenchloride; N-Bromosuccinimide; hydroxylamine hydrochloride; sodium hydride; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane; ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm030025j
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 86 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 6 h / Heating
2: NaH / tetrahydrofuran / 3 h
3: 2.4 g / HCl(g) / ethyl acetate / 0 - 20 °C
4: 86 percent / EDC; HOBT; Et3N / dimethylformamide / 20 °C
5: 100 percent / HCl / ethyl acetate / 3 h / 20 °C
6: 72 percent / iPr2NEt / acetonitrile / 48 h / 20 °C
7: 96 percent / aq. NH2OH*HCl; Na2CO3 / ethanol / 1 h / Heating
With
hydrogenchloride; N-Bromosuccinimide; hydroxylamine hydrochloride; sodium hydride; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane; ethanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm030025j