ethane-1,2-diyl bis(4-hydroxy-3-methoxybenzoate)

Base Information

• Chemical Name: ethane-1,2-diyl bis(4-hydroxy-3-methoxybenzoate)
• CAS No.: 3273-13-0
• Molecular Formula: C18H18 O8
• Molecular Weight: 362.336
• Mol file: 3273-13-0.mol

Synonyms:NSC 16735

Chemical Property of ethane-1,2-diyl bis(4-hydroxy-3-methoxybenzoate)

Chemical Property:

• Vapor Pressure: 7.17E-14mmHg at 25°C
• Boiling Point: 576.1°Cat760mmHg
• Flash Point: 207.8°C
• Density: 1.337g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethane-1,2-diyl bis(4-hydroxy-3-methoxybenzoate)

There total 5 articles about ethane-1,2-diyl bis(4-hydroxy-3-methoxybenzoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

ethane-1,2-diyl bis-[3-methoxy-4-[(methoxycarbonyl)oxy]benzoate] (1222381-97-6) → 2-(4-hydroxy-3-methoxybenzoyl)oxyethyl-4-hydroxy-3-methoxybenzoate (3273-13-0)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; at 20 ℃; for 1.66667h;

Reference yield: 49.0%

C32H30O8 (1234569-92-6) → 2-(4-hydroxy-3-methoxybenzoyl)oxyethyl-4-hydroxy-3-methoxybenzoate (3273-13-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; Cooling with ice;

DOI:10.1016/j.bmc.2010.04.047

Reference yield:

4-ethoxycarbonyloxy-3-methoxy-benzoic acid (84462-03-3) → 2-(4-hydroxy-3-methoxybenzoyl)oxyethyl-4-hydroxy-3-methoxybenzoate (3273-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / Behandeln einer aether. Loesung des Saeurechlorids mit der Dinatrium-Verbindung des Aethylenglykols in Wasser

With thionyl chloride;

DOI:10.1021/ja01171a086

upstream raw materials:

1,2-bis-(4-ethoxycarbonyloxy-3-methoxy-benzoyloxy)-ethane

3-methoxy-4-hydroxybenzoic acid

ethylene glycol

4-ethoxycarbonyloxy-3-methoxy-benzoic acid

Refernces

• 1、 Lamoral-Theys, Delphine,Pottier, Laurent,Kerff, Frédéric,Dufrasne, Fran?ois,Proutière, Fabien,Wauthoz, Nathalie,Neven, Philippe,Ingrassia, Laurent,Antwerpen, Pierre Van,Lefranc, Florence,Gelbcke, Michel,Pirotte, Bernard,Kraus, Jean-Louis,Nève, Jean,Kornienko, Alexander,Kiss, Robert,Dubois, Jacques. "Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli". experimental part. p. 3823 - 3833. Retrieved 2010/08/19.